Summary
It has been suggested that ischaemia is an important factor in the conversion of oedematous to haemorrhagic pancreatitis. In the isolated perfused canine pancreas experimental oedematous pancreatitis was induced by two different techniques. These models of pancreatitis were subjected to ischaemia by hypoxia and by decreasing blood flow. The results demonstrate that relative ischaemia alone does not result in progression of oedematous to haemorrhagic pancreatitis. It is therefore probable that ischaemia is only one of several factors which contribute to exacerbation of clinical pancreatitis.
References
Adams, T. W. and Musselman, M. M. 1953. Pancreatic venous thrombosis as an etiologic factor in acute necrotizing haemorrhagic pancreatitis. Surg. Forum. 34, 401.
Augier, D., Boucard, J. P., Pascal, J. P.et al. 1972. Relationships between blood flow and secretion in the isolated perfused canine pancreas. J. Physiol. 221, 55–69.
Broe, P. J., Cameron, J. L. 1982. Experimental gallstone pancreatitis: Pathogenesis and response to different treatment modalities. Ann. Surg. 195, 566–573.
Broe, P. J., Zuidema, G. D., Cameron, J. L. 1982. The role of ischaemia in acute pancreatitis studies with an isolated perfused canine pancreas. Surgery. 91, 377–382.
Frey, C. F. 1979. Haemorrhagic pancreatitis. Amer. J. Surg. 137, 616–624.
Goodhead, B. 1969. Acute pancreatitis and pancreatic blood flow. Surg. Gynec. Obstet. 129, 331–340.
Hermon-Taylor, J. 1968, A technique for perfusion of the isolated canine pancreas. Gastroenterology 55, 488–501.
Popper, H. L., Necheles, H., Russell, K. L. 1948. Transition of pancreatic oedema into pancreatic necrosis. Surg. Gynec. Obstet. 87, 79–82.
Saharia, P., Margolis, S., Zuidema, G. D. and Cameron, J. L. 1977. Acute pancreatitis with hyperlipaemia: studies with an isolated perfused canine pancreas. Surgery. 82, 62–67.
Warshaw, A. L. and O’Hara, P. J. 1978. Susceptibility of the pancreas to ischaemic injury in shock. Ann Surg. 188, 197–201.
Wright, P. W. and Goodhead, B. 1970. The value of dextrans in the treatment of experimental pancreatitis. Surgery. 67, 807–815.
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Broe, P.J., Cameron, J.L. Experimental oedematous pancreatitis: the effects of ischaemia. I.J.M.S. 155, 83–88 (1986). https://doi.org/10.1007/BF02940055
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DOI: https://doi.org/10.1007/BF02940055