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Ion distribution in bovine tracheal smooth muscle and its modification by histamine

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Summary

The content of Na, K and Cl and the extracellular space were measured in isolated strips of smooth muscle from the bovine trachea, in normal physiological solution and in the presence of histamine (65 μmol/l). Histamine produced small increases in cell content of Na and K, and a large decrease in Cl. Histamine also produced a large increase in the measured rate of efflux of radioactive Cl, but only small changes in the effluxes of tracer Na and K. It is suggested that the depolarization of the cell membrane caused by histamine is the result of an increase in the membrane’s permeability to chloride ions.

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Authors and Affiliations

  1. Physiology Department, The Queen’s University of Belfast, UK

    C. T. Kirkpatrick & Caroline G. Bullock

Authors
  1. C. T. Kirkpatrick
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  2. Caroline G. Bullock
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Additional information

This work was supported by grants from the Medical Research Council. The skilled technical help of Linda Head and Melanie Kirkpatrick (née Elmore) is gratefully acknowledged. The results were included in the Ph.D. thesis of C.G.B.

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Kirkpatrick, C.T., Bullock, C.G. Ion distribution in bovine tracheal smooth muscle and its modification by histamine. I.J.M.S. 155, 67–73 (1986). https://doi.org/10.1007/BF02940052

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  • DOI: https://doi.org/10.1007/BF02940052

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