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Transformation von Deoxynivalenol durch die Darmflora des Schweines — In-vitro Untersuchungen zur Adaptation in Abhängigkeit von der Darreichungsform

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Abstract

To examine the biotransformation of Deoxynivalenol (DON) by the normal gut flora of pigs (in reliance on toxin-source) an in-vitro system was established. Suspensions of rectum contents from different treated animals were incubated with pure DON. Despite fast adaptation of microflora (Deepoxidation of DON) of animals fed wheat diet, no effects on reduced feed consumption and weight gain were seen. Even fast adaptation of microflora (lower intestine) couldn’t avoid DON-effects in vivo.

Zusammenfassung

Zur Untersuchung der Transformation von Deoxynivalenol (DON) durch die Darmflora des Schweines (in Abhängigkeit der Toxin-Quelle) wurde ein in-vitro-System etabliert. Hierzu wurde rektal entnommener Kot unterschiedlich behandelter Tiere in einem anaeroben Puffergemisch mit reinem DON inkubiert. Obwohl die Mikroflora der mit Weizen gefütterten Tiere sehr schnell in der Lage war DON zu deepoxidieren, konnte hierdurch die negative DON-Wirkung nicht verhindert werden.

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Literaturverzeichnis

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Authors and Affiliations

  1. Institut für Tierernährung (450), Universität Hohenheim, Emil-Wolff-Strasse 10, 70599, Stuttgart, Deutschland

    Lauber U, Dillenburger T, Schollenberger M, Müller HM & Drochner W

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  1. Lauber U
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  2. Dillenburger T
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  3. Schollenberger M
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  4. Müller HM
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  5. Drochner W
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Lauber, U., Dillenburger, T., Schollenberger, M. et al. Transformation von Deoxynivalenol durch die Darmflora des Schweines — In-vitro Untersuchungen zur Adaptation in Abhängigkeit von der Darreichungsform. Mycotox Res 16 (Suppl 2), 166–169 (2000). https://doi.org/10.1007/BF02940028

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  • DOI: https://doi.org/10.1007/BF02940028

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