Summary
THE clinical features of fifty successive patients with systemic lupus erythe matosus (SLE) presenting to a tertiary referral rheumatology department were examined. Forty-nine patients were born in Ireland, giving an opportunity to seek racial or environmental factors which might modify disease expression and clinical course. However, mean age at onset, clinical features and five year survival did not differ from other Caucasion populations reported in the literature. This study failed to provide evidence which might suggest that environmental or genetic factors influence clinical course of SLE in Ireland.
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Arnett, F. C., Reveille, J. D., Wilson, R. W., Provost T. T., Bias, W. B. 1984. Systemic Lupus Erythematosus: Current status of the genetic hypothesis. Semin. Arthritis Rheum. 14, 1, 24–34.
Ballou, S. P., Khan, A. M., Kushner, I. 1982. Clinical features of systemic lupus erythematosus, differences related to race and age of onset. Arthritis Rheum. 25, 1, 55–60.
Brandt, K. D., Lessell, S. 1978. Migranous phenomena in systemic lupus erythematosus. Arth. ritis Rheum. 21, 7–16.
Bresnihan, B., O’Connell, A. 1982. Systemic lupus erythematosus, cerebral disease and intellectual function. Arthritis Rheum. 25, 582.
Fries, J. F., Porta, J., Liang, M. H. 1978. Marginal benefit of renal biopsy in systemic lupus erythematosus. Arch. Int. Med. 138, 1386–1389.
Grigor, R., Edmonds, J., Lewkonia, R., Bresnihan, B., Hughes, G. 1978. Systemic Lupus Erythematosus: a prospective analysis. Ann. Rheum. Dis. 37, 121–128.
Hughes, G. 1982. The treatment of SLE: the case for conservative management. Clin. Rheum. Dis. 8, 299–313.
Kaslow, R. A., Masi, A. T. 1978. Age, sex and race; effects on mortality from systemic lupus erythematosus. Arthritis Rheum. 21, 473–479.
Kiernan, M., Bresnihan, B. 1983. Clinical features and outcome of infection in systemic lupus erythematosus. Irish J. Med. Sci. 152, 10, 382–386.
Levinsky, L., Cummiskey, J., Romer, F. K., Wurm, K., Buss, J., Dorken, M., Steinbruck, P., Burlikov, T., Blasi, A., Oliveri, D., Mariana, B., Bisetti, A., Goldman, S., Djuric, B., Lazarous, P., Celikoglu, S. I. 1976. Sarcaidosis in Europe: A cooperative study. Proceedings of the 7th International Conference of Sarcoidosis and other granulomatous disorders. Ann. N.Y. Acad. Sci. 278, 335–346.
Logan, J. 1963. Prevalence of sarcoidosis in the Irish Republic: Proceedings of the 3rd International Conference on Sarcoidosis. ACTA Med. Scand. (supplement) 425, 1964, p9, 126.
McCarthy, C. F., Mylotte, M., Stevens, F., Egan-Mitchell, B., Fottrell, P. F., McNicholl, B. 1974. Family studies on coeliac disease in Ireland. Proceedings of the 2nd International Coeliac Symposium, Leiden Stenfert, Knoesi. p9, 311.
Merrell, M., Shulman, L. E. 1955. Determination of prognosis in chronic diseases. J. Chron. Dis. 1, 12–32.
Mongey, A. B., Glynn, D., Hutchinson, M., Bresnihan, B. 1985. Clinical neurophysiology in the assessment of neurological lupus. Brit. J. Rheumatol. 24, 207.
Rothfield, N. 1981. Clinical features of systemic lupus erythematosus. Textbook of Rheumatology. Eds. Kelley, W. N., Harris, E. D., Ruddy, S., Sledge, C. B. W. B. Saunders Co., Philadelphia. 1106–1132.
Serdula, M. K., Rhoads, G. G. 1979. Frequency of systemic lupus erythematosus in different ethnic aroups in Hawaii. Arthritis Rheum. 22, 328–333.
Tan, E. M., Cohen. A. S., Fries, F. F., Masi, A. T., McShane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., Winchester, R. J. 1982. The revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25, 11, 1271–1277.
Wold, R. T., Young, F. E., Tan, E. M., Farr, R. S. 1968. Deoxyribonucleic acid antibodies: a method to detect its primary interaction with deoxyribonucleic acid. Science 161, 806–807.
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Thomas, M., Bresnihan, B. Systemic lupus erythematosus in Ireland: A review of 50 patients. I.J.M.S. 155, 1–5 (1986). https://doi.org/10.1007/BF02939942
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DOI: https://doi.org/10.1007/BF02939942