Summary
The investigation of biochemical alterations in vitamin D metabolism was undertaken in institutionalized epileptic patients receiving anticonvulsant therapy. The influencing factors assessed included : anticonvulsant therapy, U.V. exposure, diet, and mobility. The epileptic group was compared to a group of non epileptic institutionalized patients and a group of normal healthy controls. Calcium and alkaline phosphatase were significantly altered in the epileptic group compared to the other two groups. However 250 HD levels were similarly reduced in the two institutionalized groups compared to controls. U.V. exposure, diet and mobility influenced vitamin D metabolism, however anticonvulsants had a more severe effect on bone mineral metabolism.
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This study was sponsored by Warner Lambert and the Irish Epilepsy Association. We wish to thank Dr. McCarthy, Clinical Director of Cork Polio for allowing us to assess these children and to thank the staff for their co-operation at all times. We would like to express our appreciation to the Statistics Department, University College Cork for their assistance and use of facilities. We also wish to thank the Biochemistry Department for their assistance and Ms. Heather Donovan for her secretarial assistance.
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Gough, H., Bissesar, A., Goggin, T. et al. Factors associated with the biochemical changes in vitamin d and calcium metabolism in institutionalized patients with epilepsy. I.J.M.S. 155, 181–189 (1986). https://doi.org/10.1007/BF02939839
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DOI: https://doi.org/10.1007/BF02939839