Abstract
The purpose was to observe the effect on sarcomagenesis of 3 substances reported to inhibit neoplastic growth — interferon alpha-2/alpha-1 hybrid (IFN), 5-iodo-2-deoxyuridine (IUdR) and methylglyoxal bis(guanylhydrazone) (MGBG). Inhibitory effect might help diminish the sarcoma risk of human implants.
The substances were applied respectively to groups of 25mm cellulose filters which were implanted subcutaneously 1 per animal in randomly assigned respective groups of 50 female BALB/c mice. The implant sites were palpated weekly. On detection of a tumour the animal was sacrificed. The number of tumours arising and the accumulated weeks of exposure to the implants were recorded per group and compared to those of controls with untreated filters.
Tumour incidence in the 2 IFN groups was 33/45 and 35/48 mice — 160 per cent that of the controls, 22/48 (chi-square p<0.05). In the IUdR group tumour incidence was 24/44 mice — 194 per cent that of controls (p<0.05), and in the MGBG group 15/43 – 122 per cent that of controls (p<0.75).
Although the substances inhibit tumour growth in man, they did not inhibit but increased film sarcomagenesis, not significant for MGBG. Observation of the effects of such substances with dual neoplastic activity may furnish clues to the control processes of neoplasia.
Similar content being viewed by others
References
Jennings, T. A., Peterson, A., Axiotis, A. M., Friedlander, R. A., Cooke, R. A., Rosai, J. Angiosarcoma associated with foreign-body material. Cancer: 1988; 62: 2436–2444.
McCarthy, P. E., Helund, C. S., Veazy, R. S., Prescott-Matthews, J., Cho, D. Y. Liposarcoma associated with a glass foreign body. Am. Vet. Med. Assoc. 1996; 209: 612–614.
Turner, F. C. Sarcomas at sites of subcutaneously implanted bakelite disks. J. Natl. Cancer Inst. 1941; 2: 81–83.
Oppenheimer, B. S., Oppenheimer, E. T., Danishefsky, I., Stout, A. P., Eirich, F. R. Further studies on polymers as carcinogenic agents in animals. Cancer Res. 1955; 55: 330–334.
Bischoff, F., Bryson, G. Carcinogenesis through solid state surfaces. Prog. Exp. Tumor Res. 1964; 5: 85–183.
Brand, G. K., Bouen, L. C., Johnson, K., Brand, Inge. Etiological factors, stages, and the role of the foreign body in foreign body tumorigenesis: a review. Cancer Res. 1975; 35: 279–286.
Lavelle, S. M. Action of histone on neoplastic and normal growth. Ir. J. Med. Sci. 1973; 142: 58–65.
Lavelle, S. M. Enhancing and inhibiting effects of histone fractions on film sarcoma. Ir. J. Med. Sci. 1978; 147: 145–150.
Lavelle, S. M., MacIomhair, M. Enhancing effect of polyamines on yield of film sarcoma. Eur. J. Cancer. Clin. Oncol. 1984; 20: 503–506.
MacIomhair, M., Lavelle, S. M. The effect of growth factors on foreign-body sarcoma in the mouse. Med. Sci. Res. 1998; 26: 445–446.
Krim, M. Understanding interferons: effect of interferons on tumour cells. Interferon Letter 1986; 1: 1–3.
Mattson, K., Niiranen, A., Ruotsalainen, T. et al. Interferon maintenance therapy for small cell lung cancer: improvement in long-term survival. J. Interferon & Cytokine Res. 1997; 17: 103–105.
Gresser, I. Wherefore interferon? J. Leukocyte Biol. 1997; 61: 567–574.
Rizzo, J., Levine, A. M., Weiss, G. R. et al. Pharmacokinetic profile of mitoguazone (MGBG) in patients with AIDs related non Hodgkin’s lymphoma. Invest. New Drugs 1996; 14: 227–234.
Levine, A. M., Tulpule, A., Tessman, D. et al. Mitoguazone therapy in patients with refractory or relapsed AIDS-related lymphoma: results from a multicenter phase II trial. J. Clin. Oncology 1997; 15: 1094–1103.
Sullivan, F. H., Herscher, L. L., Cook, J. A. et al. National Cancer Institute (phase 11) study of high-grade glioma treated with accelerated hyperfractionated radiation and iododeoxy-uridine: results in anaplastic astrocytoma. Int. J. Radiation Oncology, Biology, Physics 1994; 30: 583–590.22.
Reynolds, J. E. F. ed. Martindale, the extra pharmacopoeia (30th edition). London. Pharmaceutical Press. 1993. 652
Lavelle, S. M., MacIomhair, M. The reliability of thrombotic tendency measured by intravascular wires in the rat. Thromb. Res. 1997; 87: 353–357.
Johnson, K. H., Buoen, L. C., Brand, I., Brand, K. G. Polymer tumorigenesis: clonal determination of histopathological characteristics during early preneoplasia: relationship to karyotype, mouse strain and sex. 1970. J. Nat. Cancer Inst. 44: 785–793.
Oppenheimer, B. S., Oppenheimer, E. T., Stout, A. P., Willhite, M., Danishefsky, I. The latent period in carcinogenesis by plastics in rats and its relation to the presarcomatous phase. Cancer 1958; 11: 204–210.
Ferguson, D. J. Cellular attachment to implanted foreign bodies in relation to tumorigenesis. Cancer Res. 1977; 37: 4367–4371.
Karp, R. D., Johnson, K. H., Buoen, L. C., Ghobrial, H. G., Brand, I., Brand, G. K. Tumorigenesis by Millipore filters in mice: histology and ultrastructure of tissue relations as related to pore size. J. Natnl. Cancer Inst. 1973; 51: 1275–1285.
Bates, R. R., Prehn, R. T. The role of the fibrous capsule in carcinogenesis by plastic film. Nature 1965; 205: 303–304.
James, S. J., Pogriba, M., Miller, B. J., Bolon, B., Muskhelishvili, L. Characterisation of cellular response to silicone implants in rats: implications for foreign-body carcinogenesis. Biomaterials 1997; 18: 667–675.
MacIomhair, M., Lavelle, S. M. The effect of film size on production of foreign body sarcomas by perforated film implants. Technol. and Hlth. Care 1997; 5: 331–334.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Iomhair, M.M., Lavelle, S.M. Effect of 3 growth control substances on foreign body sarcomagenesis: IFN, IUdR, MGBG. Ir. J. Med. Sc. 168, 42–44 (1999). https://doi.org/10.1007/BF02939580
Issue Date:
DOI: https://doi.org/10.1007/BF02939580