Skip to main content

Effect of radiotherapy on plasma and tumour ascorbic acid levels

Abstract

In 21 patients plasma ascorbic acid levels were estimated sequentially during their course of radiotherapy. These levels were found to decline from a mean of 0.5 mg/dl to 0.3 mg/dl during a typical course of radiotherapy. This effect was more noticeable for therapy to abdominal sites than other areas, such as the head or neck. In a separate study of 16 patients with accessable tumours, the tumour ascorbic acid levels were estimated sequentially during a course of radiotherapy. These levels increased during therapy from a mean of 11.5 mg/ 100 g to 14.5 mg/100 g. The likely explanation of these observations is discussed and their implications explored in view of recent indications that vitamin C may exert a radioprotective effect.

This is a preview of subscription content, access via your institution.

References

  • Densen, K. W. and Bowers, E. F. 1961. The determination of ascorbic acid in white blood cells. Clin. Sci. Mol. Med. 21, 157.

    Google Scholar 

  • Freeman, J. R. and Hughes, R. E. 1963. The growth-maintaining activity of ascorbic acid. Brit. J. Nutrit. 17, 251.

    Article  Google Scholar 

  • Kakar, S. C., Wilson, C. W. M. and Moriarty, M. J. 1977. The relationship between cancer, radiotherapy and vitamin C. Irish J. Med. Sci. 146, 289.

    PubMed  CAS  Google Scholar 

  • Miller, T. R. and Sokoloff, B. 1955. A vitamin C free diet in radiation therapy of malignant disease. Amer. J. Roentgenology. 73, 472.

    CAS  Google Scholar 

  • Moriarty, M. J., Mulgrew, S., Malone, J. F. and O’Connor, M. K. 1977. Results and analysis of tumour levels of ascorbic acid. Irish J. Med. Sci. 146, 74.

    PubMed  CAS  Google Scholar 

  • Moriarty, M. J., Mulgrew, S., Mothersill, C., Malone, J. F. and Hatch, M. 1978. Some defects of large doses of vitamin C in patients with malignant disease. Irish J. Med. Sci. 148, 166.

    Google Scholar 

  • Mothersill, C., Malone, J. F., O’Connor, M. K. and Moriarty, M. J. 1978. Vitamin C and redioprotection. Brit. J. Radiol. 51, 474.

    CAS  Article  Google Scholar 

  • O’Connor, M. K., Malone, J. F., Mulgrew, S. and Moriarty, M. J. 1977a. A radioprotective effect of vitamin C observed in Chinese Hamster Ovary Cells. Brit. J. Radiol. 50, 587.

    PubMed  CAS  Google Scholar 

  • O’Connor, M. K., Malone, J. F. and Moriarty, M. J. 1977b. Protective effect of high concentrations of vitamin C on the radiation response of Chinese Hamster Ovary cells.In: Proceedings of Fourth International Conference on Radiation Protection, Paris. In.t Radiation Protection Association, Vol. 4, p. 1307.

    Google Scholar 

  • Wilson, C. W. M. 1974. Vitamin C tissue saturation, metabolism and desaturation. Practitioner. 212, 481.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Moriarty, M.J., Mulgrew, S., Malone, J.F. et al. Effect of radiotherapy on plasma and tumour ascorbic acid levels. IJMS 149, 246–251 (1980). https://doi.org/10.1007/BF02939148

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02939148

Keywords

  • Radium
  • Ascorbic Acid
  • Chinese Hamster Ovary Cell
  • Seminoma
  • Ascorbic Acid Level