Summary
The effect of dietary fibre on gastroenteropancreatic hormone release was studied in 12 healthy adults. The following results were obtained after high fibre as compared with a low fibre meal: plasma glucose was lower at 60 minutes (p<0.02); plasma glucagon was elevated at 30 and 60 minutes (p<0.01, <0.001 respectively); no changes were observed in V.I.P. or gastrin levels. These data suggest a possible hormonally mediated effect of fibre on colonic motility.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Burkitt, D. P. 1975. Dietary fibre and pressure diseases. J. Roy. Coll. Phys. 9, 138.
Chowdhury, A. R. and Lorber, S. H. 1977. Effects of glucagon and secretin on food or morphine-induced motor activity of the distal colon, rectum and anal sphincter. Amer. J. Dig. Dis. 22, 775.
Cowgill, G. R. and Anderson, W. E. 1932. Laxative effects of wheat bran and “washed bran” in healthy man. A comparative study. J. Amer. Med. Assn. 8, 1866.
Eastwood, M. A., Kirkpatrick, J. R., Mitchell, W. D., Bone, A. and Hamilton, T. 1973. Effects of dietary supplements of wheat bran and cellulose on faeces and bowel function. Brit. Med. J. iv, 392.
Fahrenkrug, J. and Schaffalitzky de Muckadell, O. B. 1977. Radioimmunoassay of vasoactive intestinal polypeptide (VIP) in plasma. J. Lab. Clin. Med. 89, 1379.
Fantus, B. and Frankl, W. 1941. The mode of action of bran. I. Effect of bran upon composition of stools. J. Lab. Clin. Med. 26, 1774.
Grimes, D. S. and Goddard, J. 1977. Gastric emptying of whole meal and white bread. Gut 18, 725.
Grossman, M. I. 1974. Gastrointestinal hormones: spectrum of actions and structure activity relations.In: Endocrinology of the Gut. Eds. W. Y. Chey, F. P. Brooks. Thorofare, New Jersey. Slack C. B. Inc. p. 65.
Jemmali, M. and Rodriguez-Kabana, R. 1970. A polarographic method for rapid determination of glucose with glucose oxidase. Analyt. Biochem. 37, 253.
Jenkins, D. J. A., Leeds, A. R., Gassull, M. A., Cochet, B. and Alberti, K. G. M. M. 1977. Decrease in postprandial insulin and glucose concentrations by guar and pectin. Ann. Int. Med. 86, 20.
Kirwan, W. O., Smith, A. N., McConnell, A. A., Mitchell, W. D. and Eastwood, M. A. 1974. Action of different bran preparations on colonic function. Brit. Med. J. iv, 187.
Klevay, L. M. 1974. Coronary heart disease and dietary fiber. Am. J. Clin. Nutr. 27, 1202.
McCance, R. A., Prior, K. M. and Widdowson, E. M. 1953. A radiological study of the rate of passage of brown and white bread through the digestive tract of man. Brit. J. Nutr. 7, 98.
Southgate, D. A. T. 1973. Fibre and the other unavailable carbohydrates and their effects on the energy value of the diet. Proc. Nutr. Soc. 32, 131.
Srivastava, G. S., Smith, A. N. and Painter, N. S. 1976. Sterculia bulk-forming agent with smooth muscle relaxant versus bran in diverticular disease. Brit. Med. J. i, 315.
Taylor, I. and Duthie, H. H. 1976. Bran tablets and diverticular disease. Brit. Med. J. i, 988.
Trowell, H. C. 1973. Dietary fibre, ischaemic heart disease and diabetes mellitus. Proc. Nutr. Soc. 32, 151.
Unger, R. H., Eisentraut, A. M., McCall, M. S. and Madison, L. L. 1961. Glucagon antibodies and an immunoassay for glucagon. J. Clin. Invest. 40, 1280.
Wilson, M. J., Dickson, W. H. and Singleton, A. C. 1929. Rate of evacuation of various foods from the normal stomach. Arch. Intern. Med. 44, 787.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Connell, A.M., McCarroll, A.M. & Chen, M.H. Effect of fibre from bran crereal on gastroenteropancreatic hormone response of normal adults. IJMS 149, 49–52 (1980). https://doi.org/10.1007/BF02939110
Issue Date:
DOI: https://doi.org/10.1007/BF02939110