Summary
Changes in energy metabolism of canine renal cortex were investigated immediately after nephrectomy and following flushout with two solutions. Even a brief period of ischaemic produced a sharp fall in adenine nucleotide concentration: further fall was prevented by flushout with cold Ringer’s solution and some restoration of nucleotides was achieved by flushing with a modified Collins’ solution.
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References
Adam, H. 1962. In Bergmeyer, H. V.: Methods of Enzymatic Analysis. 1st edition, Verlag chemie, Weinheim. p. 573.
Adam, H. 1965. In Bergmeyer, H. V.: Methods of Enzymatic Analysis. 2nd edition, Verlag Chemie, Weinheim. p. 539.
Belzer, F. O., Ashby, B. S. and Dunphy, J. E. 1967. 24-hour and 72-hour preservation of canine kidneys. Lancet ii, 536.
Calman, K. C. 1973. Metabolic aspects of organ storage and the prediction of organ viability: an hypothesis. Surgical Research Society Meeting, January, 1973.
Chapman, J. 1971. Hypothermic perfusion preservation of the canine kidney with a simulated intracellular fluid. Brit. J. Urol. 43, 421.
Collins, G. M., Hartley, L. C. J. and Clunie, G. J. A. 1972. Kidney preservation for transportation. Experimental analysis of optimal perfusate composition. Brit. J. Surg. 59, 187.
Farber, E. 1973. ATP and cell integrity. Fed. Proc. 32, 1534.
Fox, I. H. 1974. Purine ribonucleotide catabolism: clinical and biochemical significance. Nutr. Metabol. 16, 65.
Grundmann, R., Landes, T. and Pichlmaier, H. 1972. Hypothermic pulsatile perfusion of dog kidneys. Transplantation Vol. 14, No. 6, 742.
Keaveny, T. V., Brien, T. G., Michalowicz, B. and FitzGerald, P. 1972. Evaluation of renal flush-out. Irish J. med. Sci. 141, 136.
Kessler, H. 1970. Effects of ischaemia on the concentration of adenine nucleotides in the kidney of anaesthetised dogs. Proc. Soc. exp. Biol. Med. 134, 1091.
Schmidt-Mende, M. and Brendel, W. 1967. Experimentelle untersuchungen zum energiestoffwechsel der kuhlkonserviertenniere. Z. Ges. exp. Med. 143, 250.
Vogt, M. T. and Farber, E. 1968. On the molecular pathology of ischaemic renal cell death. Am. J. Path. 53, 1.
Woods, J. E., Cooperman, A. M. and Mathews, L. E. 1971. An effective system for long-term organ preservation. Mayo Clin Proc. 46, 754.
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Keaveny, T.V., Cunningham, S.K. & O’Boyle, A. The response of renal cortical adenine nucleotides to different flush-out solutions. IJMS 144, 199–202 (1975). https://doi.org/10.1007/BF02939013
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DOI: https://doi.org/10.1007/BF02939013