Summary
New Zealand white rabbits were exposed to an environmental temperature of either 20°C (control) or 5°C (cold-exposure) for periods of from one to six weeks. Ear skin temperature was around 30°C in the control environment and fell to around 15°C in the cold environment. Compared with control arteries, ear arteries from cold-exposed animals tended to have a lower optimal temperature for responses to injected noradrenaline (NOR). At 37°C, responses of control arteries exceeded those of cold-exposed arteries; at 12°C the situation was reversed. A similar “cross-over” effect was observed with responses to electrical stimulation (ES). However, in both groups of arteries, responses to ES were better preserved than were responses to NOR at low temperatures, possibly because cooling interfered with uptake into neuronal stores of NOR released by ES, thus allowing more NOR to reach the arterial muscle at these low temperatures.
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References
Bazett, H. C., Love, L., Newton, M., Eisenberg, L., Day, R. and Forster, R. 1948. Temperature changes in blood flowing in arteries and veins in man. J. appl. Physiol., 1, 3.
Birmingham, A. T. 1970. Sympathetic denervation of the smooth muscle of the vas deferens. J. Physiol., 206, 645.
de la Lande, I. S., Frewin, D. and Waterson, J. G. 1967. The influence of sympathetic innervation on vascular sensitivity to noradrenaline. Br. J. Pharmac. Chemother., 31, 82.
de la Lande, I. S. and Rand, M. J. 1965. A simple isolated nerve-blood vessel preparation. Aust. J. Ex. Biol. med. Sci., 43, 639.
Glover, W. E., Strangeways, D. H. and Wallace, W. F. M. 1968. Responses of isolated ear and femoral arteries of the rabbit to cooling and to some vasoactive drugs. J. Physiol., 194, 78P.
Herron, A., Mock, G. R. and Wallace, W. F. M. 1971. Evidence for a non-specific sensitizing action of physostigmine (eserine) on constrictor responses of smooth muscle in the rabbit ear artery. J. Physiol., 216, 61P.
Joyce, C. M. 1967. The effect of environmental temperature on succinic dehydrogenase activity in the ear skin of the rabbit. Proc. R. Ir. Acad., 65, B, 425.
Keatinge, W. R. 1958. The effect of low temperatures on the responses of arteries to constrictor drugs. J. Physiol., 142, 395.
Kluger, M. J., Gonzalez, R. R. and Hardy, J. D. 1972. Peripheral thermal sensitivity in the rabbit. Am. J. Physiol., 222, 1031.
McClelland, R. J., McGrann, S. and Wallace, W. F. M. 1969. Evidence that the responses of the perfused rabbit ear artery are influenced by the environmental conditions of the animal. J. Physiol., 205, 5P.
Martin, R. P. and Wallace, W. F. M. 1970. The effect of temperature on the response of the perfused rabbit ear artery to electrical stimulation. J. Physiol., 207, 80P.
Paton, W. D. M. 1955. The response of the guinea-pig ileum to electrical stimulation by coaxial electrodes. J. Physiol., 127, 40P.
Smith, D. J. 1953. Variations in vascular reactivity produced by season, cold stress and immaturity; role of thyroid and adrenal cortex. Am. J. Physiol., 172, 118.
Smith, D. J., Syverton, J. T. and Coxe, J. W. 1951. In vitro studies of the coronary arteries of man and swine as demonstrated by a new technic, angioplethysmokymography. Circulation, 4, 890.
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Martin, R.P., McClelland, R.J. & Wallace, W.F.M. Effect of cold exposure of the rabbit on the subsequent performance of its isolated ear artery with respect to temperature. IJMS 144, 191–198 (1975). https://doi.org/10.1007/BF02939012
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DOI: https://doi.org/10.1007/BF02939012