Summary
A case of infertility associated initially with amenorrhoea only and then with amenorrhoea and galactorrhoea following a successfully induced pregnancy is reported. In a period of eight years of continuous investigation and treatment this subject’s infertility first responded to sequential clomiphene and human chorionic gonadotrophin (HCG) therapy resulting in a normal pregnancy. Subsequently she became refractory to this therapy. The availability of specific prolactin assays and a prolactin inhibitor (2-Br-α-ergocryptine, bromocriptine Sandoz) identified the aetiology of her amenorrhoea/galactorrhoea/infertility and provided a new mode of therapy. Planned conception has been achieved on three occasions, producing two normal males and a normal female child.
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Darragh, A., O’Kelly, D.A., Browne, A.D.H. et al. Restoration of fertility in prolactin induced premature menopause. IJMS 145, 231–236 (1976). https://doi.org/10.1007/BF02938951
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DOI: https://doi.org/10.1007/BF02938951