Summary
In order to evaluate the effect of methylprednisolone sodium succinate (MPSS) on the alteration of pancreatic oxygen consumption (VO2) in hypovolemic shock, MPSS was administered to four normal canines and three hypovolemic animals. All were treated according to the protocol used in the initial report. (The Pancreas and Oxygen Consumption 1: Pancreatic Oxygen Consumption in Normo- and Hypovolemic Dogs.) All seven underwent a splenectomy at the beginning of the experiment. Pancreatic VO2, obtained by adding up VO2 for the head (minus the uncinate process) and tail of the pancreas, was equal to the product of regional blood flow,Q, determined electromagnetically on the gastroduodenal (GDA) and splenic (SA) arteries, times O2 extraction, (a-v)O2; O2 content (in mL%) was measured in the femoral artery (RFA), in the splenic (SV) and superior pancreaticoduodenal (SPDV) veins. Similar determinations were carried out on the right hind limb that served as a control.
Recordings were made for 4 h in both groups, the first hour determinations (five in all) serving as reference values. Methylprednisolone did not appear to alter pancreatic VO2, which showed a significant increasing trend from + 77% 1 h after MPSS had been given, to + 98% 3 h later (vs + 56 and +92%, respectively, in the control group). As in the control group, these increases were owing to augmented O2 extraction by the pancreas. No significant change was noted between the head and tail of the pancreas. In the hind limb, VO2 increased significantly the first 2 h and differed from control VO2 at the end of the first hour only.
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References
Feiner H. Pancreatitis after cardiac surgery. A morphologic study. Am J Surg 1976; 131: 684–688.
Warshaw AL and O’Hara PJ. Susceptibility of the pancreas to ischemic injury in shock. Ann Surg 1978; 188: 197–201.
Hegewald G, Nikulin A, Gmaz-Nikulin E, Plamenac P, and Barenwald G. Ultrastructural changes of the human pancreas in acute shock. Path Res Pract 1985; 179: 610–615.
Barzilai A, Ryback BJ, Medina JA, Toth L, and Dreiling DA. The morphological changes of the pancreas in hypovolemic shock and the effect of pretreatment with steriods. Int J Pancreatol 1987; 2: 23–32.
Robert JH, Toledano AE, Huang G, Toth LS, Premus G, Papp M, and Dreiling DA. Pancreatic oxygen consumption in normo- and hypovolemic dogs. Submitted to publication.
Eskwith IS, Cacace VA, and Sollosy A. Acute hemorrhagic pancreatitis. Treatment with cortisone. New Engl J Med 1955; 252: 494, 495.
Rogers NC, Wilson AO, Meynell MJ, and Cooke WT. Treatment of acute pancreatitis with cortisone. Lancet 1956; 2: 651, 652.
Kaplan MH. ACTH and cortisone in gastroenterology. Am J Gastroenterol 1957; 27: 163–179.
Anderson MC, Mehn WH, and Method HL. Treatment of acute hemorrhagic pancreatitis with adrenocorticoids. Clinical and experimental observations. AMA Arch Surg 1959; 78: 146–153.
Studley JGN and Schenk WG, Jr. Pathophysiology of acute pancreatitis. Evaluation of the effect and mode of action of steroids in experimental pancreatitis in dogs. Am J Surg 1982; 143: 761–764.
Kimura T, Zuidema GD, and Cameron JL. Acute pancreatitis. Experimental evaluation of steroid, albumin and Trasylol therapy. Am J Surg 1980; 140: 403–408.
Delaney JP and Grim E. Influence of hormones and drugs on canine pancreatic blood flow. Am J Physiol 1966; 211: 1398–1402.
Dreiling DA, Janowitz HD, and Rolbin H. Effect of ACTH and adrenocortical steroids on external pancreatic secretion in man. New Engl J Med 1958; 258; 603–605.
Gartemann H, Zeitz M, Emde C, Stelzer M, and Riecken EO. Three-day continuous drainage of pancreatic juice in the cortisone-treated conscious rat: analysis of enzyme activities and ultrastructural changes. Cell Tissue Res 1985; 242: 191–196.
Parent J. Effects of dexamethasone on pancreatic tissue and on serum amylase and lipase activities in dogs. JAVMA 1982; 180: 743–746.
Grossman A, Boctor AM, Band P, and Lane B. Role of steroids in secretion. Modulating effect on triamcinolone and estradiol on protein synthesis and secretion from the rat exocrine pancreas. J Steroid Biochem 1983; 19: 1069–1081.
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Robert, J.H., Toledano, A.E., Huang, G. et al. The pancreas and oxygen consumption (Part 2). Int J Pancreatol 4, 353–359 (1989). https://doi.org/10.1007/BF02938470
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DOI: https://doi.org/10.1007/BF02938470