Summary
An infant with clinical and haematological features of chronic granulocytic leukaemia is described. The absence of the Philadelphia chromosome in peripheral blood and bone marrow suggested the juvenile type of this disease. However, against this were the normal levels of foetal haemoglobin and erythrocyte carbonic anhydrase. Another unusual feature is that the patient is alive and well 20 months after diagnosis without any specific antileukaemic therapy.
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Bloom, G. E., Gerald, P. S. and Diamond, L. K. 1966. Chronic myelogenous leukaemia in an infant: serial cytogenetic and foetal hemoglobin studies. Pediatrics, 38, 295.
Fox, A. M. 1970. Case of juvenile chronic myeloid leukaemia. Lancet, 1, 368.
Hardisty, R. M., Speed, D. E. and Till, M. 1964. Granulocytic leukaemia in childhood. Brit. J. Haemat., 10, 551.
Holland, P. and Mauer, A. M. 1963. Myeloid leukemoid reactions in children. Amer. J. Dis. Child. 105, 568.
Holt, S. B. 1961. Quantitative genetics of finger print patterns. Brit. med. Bull. 17, 242.
Kleihauer, E., Braun, H. and Betke, K. 1957. Demonstration von fetalem haemoglobin in den erythrocyten eines blutausstrichs. Klin. Wschr. 35, 637.
Menser, M. A. and Purvis-Smith, S. G. 1969. Dermatoglyphic defects in children with leukaemia. Lancet, 1, 1076.
Moorehead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., and Hungerford, D. A. 1960. Chromosome preparations of leucocytes cultured from peripheral blood. Exp. Cell Res. 20, 613.
Reisman, L. E. and Trujillo, J. M. 1963. Chronic granulocytic leukaemia of childhood. Clinical and cytogenetic studies. J. Pediat. 62, 710.
Rosner, F. 1969. Dermatoglyphics of leukaemic children. Lancet 2, 272.
Singer, K., Chermoff, A. I. and Singer, L. 1951. Studies on abnormal haemoglobins. II Their identification by means of a method of fractional denaturation. Blood, 6, 429.
Smith, C. H. 1966. Blood diseases of infancy and childhood. Pp. 511. The C. V. Mosby Company, St. Louis.
Weatherall, D. J. and Brown, M. J. 1970. Juvenile chronic myeloid leukaemia. Lancet, 1, 526.
Weatherall, D. J., Edwards, J. A. and Donohoe, W. T. A. 1968. Haemoglobin and red cell enzyme changes in juvenile myeloid leukaemia. Brit. med. J. 1, 679.
Weatherall, D. J. and McIntyre, P. A. 1967. Developmental and acquired variations in erythrocyte carbonic anhydrase isozymes. Brit. J. Haemat. 13, 106.
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Redmond, A., Nevin, N.C. & Bridges, J.M. An unusual case of chronic granulocytic leukaemia. I.J.M.S. 140, 327–330 (1971). https://doi.org/10.1007/BF02937778
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DOI: https://doi.org/10.1007/BF02937778