Summary
The reasons for considering that abnormal glucose absorption may be present in the blind loop syndrome are given.
Eight patients after gastric surgery, without evidence of a blind loop syndrome were compared with eight patients with evidence of a blind loop syndrome. Glucose and insulin measurements were taken after a standard oral glucose tolerance test. There was an apparent trend of lower serum insulin levels in the latter group, but this did not reach statistical significance.
The probable explanations for these findings are discussed.
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References
Chisholm, D. J., Young, D. J. and Lazarus, L. 1969. The gastro intestinal stimulus to insulin release. J. clin. Invest., 48, 1453–1460.
Curzon, G. and Walsh, J. 1962. A method for the determination of urinary indoxyl sulphate (Indican). Clin. chim. Acta. 7, 657–663.
Dawson, A. M. and Isselbacher, K. J. 1960. Studies on lipid metabolism in the small intestine with observations on the role of bile salts. J. clin. Invest, 39, 730–740.
Donaldson, R. M. Jr. 1968. Role of indigenous enteric bacteria in intestinal function and disease. Handbook of Physiology, Alimentary Canal. Washington, D.C., American Physiological Society (1968), p. 2807–2837.
Dupre, J. 1964. An intestinal hormone affecting glucose disposal in man. Lancet 2, 672–673.
Goldstein, F., Criden, L. E., Jenner, E. R. and Wirts, C. W. 1965. Bacterial utilization of d-xylose. Gastroenterology, 48, 818–819.
Greenberger, N. J., Saegh, S. and Ruppert, R. D. 1968. Urine indican excretion in malabsorptive disorders. Gastroenterology 55, 2, 204–211.
Hales, C. N. and Randle, P. J. 1963. Immunoassay of insulin with insulin antibody precipitate. Biochem. J. 88, 137–146.
Kamer, J. H. van de, Huinink, H. ten B. and Weyers, H. A. 1949. J. biol. Chem., 177, 347.
Lazarus, N. R., Voyles, N. R., Tanese, Devrim, S. and Recant, L. 1968. Extra gastrointestinal effects of secretin, gastrin and pancreozymin. Lancet 2, 248–250.
Mclntyre, N., Holdsworth, C. D. and Turner, D. S. 1964. New interpretation of oral glucose tolerance. Lancet 2, 20–21.
Mclntyre, N., Holdsworth, C. D. and Turner, D. S. 1965. Intestinal factors in the control of insulin secretion. J. clin. Endocr. 25, 1317–1324.
Neale, G. and Tabaqchali, S. 1966. Value of measuring urinary indican excretion (Abstr.) Gut 7, 711.
Samols, E. G., Marri, G. and Marks. 1965. Promotion of insulin secretion by glucagon. Lancet 2, 415–416.
Tomkin, G. H. and Love, A. H. G. Investigation of glucose transport and Co57 Vitamin B,. uptake using the everted sac technique with histological examination of the sacs after suspension in bile salts and indole. In preparation.
Tomkin, G. H., Weir, D. and Gatenby, P. B. B. Indicanuria after gastric surgery. In preparation.
Turner, D. A., Audhya, T. K., Cramp, D. G., Holdsworth, C. D. and Mclntyre, W. 1967. Effect of glucagon on intravenous glucose tolerance. Brit. med. J. 4, 145–146.
Unger, R. H., Ketterer, H., Dupre, J. and Eisentraut, A. M. 1967. Effects of secretin, pancreozymin and gastrin on insulin and glucagon secretion in anaesthetised dogs. J. clin. Invest. 46, 630–645.
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Tomkin, G.H. Carbohydrate metabolism in patients after gastric surgery. I.J.M.S. 140, 11–15 (1971). https://doi.org/10.1007/BF02937768
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DOI: https://doi.org/10.1007/BF02937768