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Prognostic factors in childhood acute lymphoblastic leukaemia

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Summary

58 patients under the age of 14 years with acute lymphoblastic leukaemia were managed from 1971 to 1985. We analysed their overall survival from diagnosis to assess the prognostic significance of clinical and laboratory features presentatdiagnosis. Factors which were statistically significant included white blood count, platelet count, palpable lymph node enlargement, mediastinal widening on chest x-ray and palpable splenic enlargement The purpose of this study was to identify that subset of patients which might have benefitted from more intensive treatment.

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References

  1. Fennelly, J. J., O’Donoghue, S., Kavanagh, T. et al. Management of childhood acute leukaemia. Journal of the Irish Medical Association. 1974: 67, 589–594.

    PubMed  CAS  Google Scholar 

  2. Peto, J., Eden, O. B., Liffeyman, J. et al. Improvement in prognosis for children with acute lymphoblastic leukaemia. Lancet 1986: 408–411.

  3. Berlin, Springer-Verlag, Lampert, F., Heinz, G., Langerman, H-J. et al. Acute lymphoblastic leukaemia: Current status of therapy in children. Recent results in cancer research. Vol. 93, 1984.

  4. Peto, R., Pike, M. C., Armitage, P. et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. British J. Cancer. 1977.

  5. Crist, W., Pullen, J., Boyett, J. et al. Acute lymphoid leukaemia in adolescents: Clinical and biologic features predict a poor prognosis — a pediatric oncology groups study. Journal Clinical Oncology 1988: 6, 34–43.

    CAS  Google Scholar 

  6. Blacklock, H., Matthews, J., Buchanan, J. et al. Improving survival poor acute lymphoblastic leukaemia in adolescents and adults. Cancer 1981: 48, 1931–1935.

    Article  PubMed  CAS  Google Scholar 

  7. Amadori, S., Meloni, G., Baccarani, M. et al. Long term survival in adolescent and adult acute lymphoblastic leukaemia. Cancer 1983: 52, 30–34.

    Article  PubMed  CAS  Google Scholar 

  8. Jacobs, A. D., Gale, R. P. Recent advances in the holugy and treatment of acute lymphoblastic leukaemia in adults. N., England Medical Journal 1984: 311, 1219–1231.

    CAS  Google Scholar 

  9. Crist, W., Pullen, J., Boyett, J. et al. Clinical and biologic features predict a poor prognosis in acute lymphoid leukaemia in infants. A pediatric oncology group study. Blood 1986: 67, 135–140.

    CAS  Google Scholar 

  10. Simonem J. J., Verzosa, M. S., Rudy, A. J. et al. Initial features and prognosis in 383 children with acute lymphocytic leukaemia. Cancer 1975: 36, 2099–2108.

    Google Scholar 

  11. Miller, R.D., Leikin, S., Albo, V. et al. Prognostic factors and therapy in acute lymphoblastic leukaemia of childhood. CCG-141. Cancer 1983: 51, 1041–1049.

    CAS  Google Scholar 

  12. Raotanen, J., Simens, M. A. Elevated serum transaminase activity at diagnosis is associated with rapidly progression disease in children with acute lymphoblastic leuk-aema. Cancer 1988: 61, 754–757.

    Article  Google Scholar 

  13. Piu, C-H., Dodge, R. K., Dahl, G. V. et al. Serum lactic dehydrogenase level has prognostic value in childhood acute lymphoblastic leukaemia. Blood, Vol 66, No. 4, October 85, pp. 778–782.

  14. Fliedner, V. Von. Contribution of immunological markers to the diagnosis and prognosis of human leukaemia. Eur. J. Cancer Clin Oncol. 1984: Vol. 21, No. 3, 347–353.

    Article  Google Scholar 

  15. Sather, H., Miller, D., Besbit, M. et al. Differences in prognosis for boys and girls with acute lymphoblastic leukaemia. The Lancet 1981: 1, 739–43.

    Article  CAS  Google Scholar 

  16. Motts, M. J. Baumer. Sex and prognosis in childhood acute leukaemia. Lancet 1978: ii, 128–129.

    Google Scholar 

  17. Motts, J. Baumer, Gentle, T. Sex and prognosis in childhood acute lymphocytic leukaemia. Lancet 1978: ii, 673.

    Google Scholar 

  18. Robinson, I., Sather, H., Coecia, P. et al. Assessment of the interrelationship of prognostic factors in childhood acute lymphocytic leukaemia. Amer. J. Ped. Hem. Oncol. 1980: 2, 5–13.

    Google Scholar 

  19. Acute lymphocytic leukaemia. U.K. Leukaemia Research Trials for Children and Adults. London: Leukemia Research Fund 1987: 20–32. Kay, H.

    Google Scholar 

  20. George, S., Fembach, D., Vietti, T. et al. Factors influencing survival in paediatric acute leukaemia. Cancer 1973: 32, 1542–53.

    Article  PubMed  CAS  Google Scholar 

  21. Evans, D., Morris-Jones, P., Hann, I. et al. Sex and prognosis in childhood acute lymphoctic leukaemia. Lancet 1978: ii, 522–523.

    Article  Google Scholar 

  22. Revesz, T., Kavdos, G., Kajtar, P. et al. The prognostic significance of bone and joint manifestations in childhood leukaemia. Journal Rheum. 1982: 3, 647–648.

    Google Scholar 

  23. Costello, P. B., Breacher, M. L., Starr, J. C. et al. A prospective analysis of the frequency, course and possible prognostic significance of the joint manifestations of childhood leukaemia. Journal Rheumatol. 1983: 10, 753–757.

    CAS  Google Scholar 

  24. Schaller, J. Arthritis as a presenting manifestation of malignancy in children. J. Paediatric 1972: 81, 793–797.

    Article  CAS  Google Scholar 

  25. Walters, T. R., Buchare, M., Simona, J. et al. Poor prognosis in negro children with acute lymphoblaslic leukaemia. Cancer 1972: 29, 210–214.

    Article  PubMed  CAS  Google Scholar 

  26. Hicosonmcz, G., Ozsoylu, S., Yetgin, S. et al. Poor prognosis of childhood acute lymphoblastic leukaemia. British Medical Journal 1983: 286, 1437.

    Google Scholar 

  27. Michael, P. M., Garson, O. M., Ekert, H., Tauro, G., Rennis, G. C. and Pilkington, G. P. Prospective study of childhood acute lymphocytic leukaemia: Haemologic, immunologic and cytogeneticcorrelations. Medical and Paediatric Oncology. 1988: 16153–161.

  28. Le Beau, M. M., Rowley, J. D. Recurring chromosomal abnormalities in leukaemia and lymphoma. pp. 371–394. Cancer Surveys, Vol 3, No. 3, 1984.

    Google Scholar 

  29. Seeker-Walker, L.M., Sylvia, D., Tawler, R. M. Hardisty. Prognostic implications of chrosomal findings in acute lymphoblastic leukaemia at diagnosis. Brirish Medical Journal 1978: 2, 1529–1530.

    Article  Google Scholar 

  30. Seeker-Walker, L. M., Swansbury, G. J., Hardisty, R. M. et al. Cytogenetics of acute lymphoblastic leukaemia in children as a factor in the prediction of long-term survival. Br. J. Haematol. 1982: 52, 389–399.

    Article  Google Scholar 

  31. Williams, D. L., Raimondi, S., Riveria, G. et al. Presence of clonal chrosome abnornmalities in virtually all cases of acute lymphoblastic leukaemia. N. Eng. J. Med. 1985: 313, 640–641.

    CAS  Google Scholar 

  32. Williams, D. L., Harber, J., Murphy, S. B. et al. Chromosomal translocations play a unique role in influencing prognosis in childhood acute lymphoblastic leukaemia blood. 1986: 68, 205–212.

    CAS  Google Scholar 

  33. Third International Workshop on Chrosomes in Leukaemia, 1981.

  34. Bloomfield, C. D., Brunning, R. D., Smith, K. A. et al. Cancer genetics and cytogenetics 1, 229–238

  35. Therapeutic manoeuvres and the prolongation of remission in childhood acute lymphocytic leukaemia with poor prognostic factors. Preliminary report - S.W.O.G. Study 7420. Abstract 767. Proc. A.A.C.R. 1979: 20, 190.

    Google Scholar 

  36. Moe, P. G., Siep, M., Finn, P. H. et al. Intermediate dose methotrexate (I.D.M.) in childhood acute lynmphocytic leukaemia in Norway. Acta Paediatric Scand. 1981: 70, 73–79.

    Article  CAS  Google Scholar 

  37. Gaynor, P. S., Bleyer, W. A., Steinherg, P. G. et al. Modified BFM therapy for children with previously untreated acute lymphoblastic leukaemia and unfavourable prognostic features. The American Journal of Paediatric Haematology/Oncology. 1988: 10(1), 42–50.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Oncology, The Children’s Hospital, Temple Street, Dublin

    J. Armstrong, M. Pomeroy, J. J. Fennelly & S. Cahalane

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  1. J. Armstrong
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  2. M. Pomeroy
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  3. J. J. Fennelly
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  4. S. Cahalane
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Armstrong, J., Pomeroy, M., Fennelly, J.J. et al. Prognostic factors in childhood acute lymphoblastic leukaemia. I.J.M.S. 159, 40–43 (1990). https://doi.org/10.1007/BF02937246

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