Skip to main content
SpringerLink
Log in

Epstein-Barr virus specific antibodies in patients with coeliac disease

  • Published:
Irish Journal of Medical Science Aims and scope Submit manuscript

Summary

SERUM antibodies to Epstein-Barr viral antigens were studied in 56 patients with treated coeliac disease and 53 healthy controls. Four individuals with a malignancy were among the group studied.

Twenty-one patients (37.5%) showed unusual antibody response patterns which were broadly divisible into two groups: (1) those with elevated antiviral capsid antigen (VCA), antibodies associated with positive anti-early antigen (EA) responses, and (2) those with low anti-Epstein-Barr nuclear antigen (EBNA) responses. While the results indicate that some patients with coeliac disease have an immunological abnormality with respect to EBV, there is as yet no direct evidence that this results in malignancies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Cooper, B. T., Holmes, G. K. T., Ferguson, R. and Cooke, W. T. 1980. Coeliac disease and malignancy. Medicine (Baltimore) 59, 249.

    CAS  Google Scholar 

  • Cornell, G. J. and Townley, R. R. W. 1973. Investigation of possible intestinal peptidase in coeliac disease. Clin. Chim. Acta 43, 113.

    Article  PubMed  CAS  Google Scholar 

  • Falchuk, Z. M. and Strober, W. 1974. Glutensensitive enteropathy: Synthesis of antigliadin antibodyin vitro. Gut 15, 947.

    Article  PubMed  CAS  Google Scholar 

  • Filipovich, A. H., Spector, B. C. and Kersey, J. 1980. Immunodeficiency in humans as a risk factor in the development of malignancy. Prevent. Med. 9, 252.

    Article  CAS  Google Scholar 

  • Hanto, D. W., Sakamoto, K., Purtilo, D. T.et al. 1981. The Epstein-Barr Virus in the pathogenesis of post-transplant lymphoproliferative disorders. Surgery 90, 204.

    PubMed  CAS  Google Scholar 

  • Harada, S., Bechtold, T., Seely, J. K. and Purtilo, D. T. 1982. Cell-mediated immunity to Epstein-Barr Virus (EBV) and natural killer (NK)-cell activity in the X-linktd lymphoproliferative syndrome. Int. J. Cancer 30, 739.

    Article  PubMed  CAS  Google Scholar 

  • Harada, S., Tatsumi, E., Lipscombe, H. and Purtilo, D. T. 1983. Responses to Epstein-Barr virus in immune deficiency patients. In Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative malignancies. Edited by D. T. Purtilo. Plenum Press, New York.

    Google Scholar 

  • Harada, S., Meuwissen, H., Bechtold, T.et al. 1984. Comparative study of immune responses to Epstein-Barr Virus of patients with X-linked lymphoproliferative syndrome (XLP) and Wiskott-Aldrich syndrome (WAS). Submitted for publication.

  • Henle, W., Henle, G. and Horwitz, C. A. 1974. Epstein-Barr virus-specific diagnostic tests in infectious mononucleosis. Hum. Path. 5, 551.

    Article  PubMed  CAS  Google Scholar 

  • Henle, W. and Henle, G. 1981. Epstein-Barr Virusspecific serology in immunologically compromised individuals. Cancer Res. 41, 4222.

    PubMed  CAS  Google Scholar 

  • Henle, W., Ho, H. C. and Kwan, H. C. 1973. Antibodies to Epstein-Barr Virus-related antigens in nasopharyngeal carcinoma. Comparison of active case with long-term survivors JNCI 51 361.

    CAS  Google Scholar 

  • Purtilo, D. T. 1981. Immune deficiency predisposing to Eustein Barr virus-induced lymphoproliferative disease: The X-linked lymphoproliferative syndrome as a model. In Advances in Cancer Research. Edited by G. Klein and S. Weinhouse. Academic Press, New York. 279.

    Google Scholar 

  • Purtilo, D. T., Sakamoto, K., Barnabei, V.et al. 1982. Epstein-Barr Virus-induced disease in boys with X-linked lymphoproliferative syndrome (XLP). Update on the studies of the registry. Am. J. Med. 73, 49.

    Article  PubMed  CAS  Google Scholar 

  • Reedman, B. M. and Klein, G. 1973. Cellular location of an Epstein-Barr virus (EVV)-associated complement-fixing antigen in producer and non producer lymphoblastoid cell lines. Int. J. Cancer 11, 499.

    Article  PubMed  CAS  Google Scholar 

  • Saemundsen, A. K., Purtilo, D. T., Sakamoto, K.et al. 1981. Documentation of Epstein-Barr Virus infection in immunodeficient patients with life-threatening lymphoproliferative disease by Epstein-Barr Virus complementary RNA/DNA and viral DNA/DNA hybridization. Cancer Res. 41, 4237.

    PubMed  CAS  Google Scholar 

  • Sakmoto, K., Freed, H. F. and Purtilo, D. T. 1980. Antibody responses to Epstein-Barr virus in families with X-linked lymphoproliferative syndrome. J. Immunol. 125, 921.

    Google Scholar 

  • Sakamoto, K., Aiba, M., Katayama, I.et al. 1981. Antibodies to Epstein-Barr Virus-specific antigens in patients with hairy-cell leukaemia. Int. J. Cancer 27, 453.

    Article  PubMed  CAS  Google Scholar 

  • Sakamoto, K., Seely, J. K., Lindsten, T.et al. 1982. Abnormal anti-Epstein-Barr virus antibodies in carriers of the X-linked lymphoproliferative syndrome and in females at risk. J. Immunol. 128, 904.

    PubMed  CAS  Google Scholar 

  • Swinson, C. M., Slavin, G., Coles, E. C. and Booth, C. C. 1983. Coeliac disease and malignancy. Lancet 15, 111.

    Article  Google Scholar 

  • Tobi, M., Morag, A., Ravid, I.et al. 1982. Prolonged atypical illness associated with serological evidence of persistent Epstein-Barr Virus infection. Lancet 9, 61.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine and the Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Centre, 42nd and Dewey Avenue, 681 05, Omaha, Nebraska

    Shinji Harada, Nancy Synder & David T. Purtilo

  2. University Department of Medicine and Pathology, Regional Hospital, Galway

    John Greally, Jack Davis, Fiona Stevens & Claran McCarthy

Authors
  1. Shinji Harada
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. John Greally
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jack Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nancy Synder
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fiona Stevens
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Claran McCarthy
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. David T. Purtilo
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

We thank Miss Patricia Rohan for typing this manuscript.

Supported in part by a grant from the Cancer Research Advancement Board of the Irish Cancer Society and by PHS grant number 30196, awarded by the National Cancer Institute, DHHS, the American Society RD161, the Nebraska Department of Health, and the Lymphoproliferative Research Fund.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harada, S., Greally, J., Davis, J. et al. Epstein-Barr virus specific antibodies in patients with coeliac disease. I.J.M.S. 154, 416–421 (1985). https://doi.org/10.1007/BF02937215

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02937215

Keywords

Search

Navigation