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Intestinal Behçet's disease associated with non-Hodgkin's lymphoma

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Abstract

A 45-year-old man with intestinal Behçet's disease noticed an enlarged right cervical lymph node, and was diagnosed with diffuse large cell type, non-Hodgkin's lymphoma. The intrapelvic lymph tract was markedly deformed because of recurrent ileocecal ulceration, and conventional lymphoscintigraphy with a common tracer did not abolish the suspicion that lymphoma cells may have invaded the lymph nodes. Dynamic lymphoscintigraphy with a new tracer,99mtechnetium-diethylene triamine pentaacetic acid-human serum albumin, because of its high detection sensitivity, was very useful for excluding this suspicion, and for determining the clinical stage of lymphoma. Combination induction chemotherapy led to complete remission without any adverse effects, but subsequent supportive therapy with same protocol could not be completed because of progression of the intestinal lesions. Special management for the intestinal lesions, such as bowel rest, may be essential with chemotherapy for patients with intestinal Behçet's disease.

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Authors and Affiliations

  1. First Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan

    Takatsugu Yamamoto, Mizue Tamura, Toshikazu Hamauzu, Akiko Nakayama, Kazuo Kawasugi, Masahide Kamakura, Tadatoshi Kinoshita, Yasushi Kuyama, Masami Yamanaka & Masaki Sanaka

  2. Department of Preventive Medicine, Division of Social Medicine, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima Bunkyo-ku, 113, Tokyo, Japan

    Takatsugu Yamamoto, Li-man Wang, Masaki Sanaka & Satoru Mineshita

Authors
  1. Takatsugu Yamamoto
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  2. Mizue Tamura
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  3. Toshikazu Hamauzu
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  4. Akiko Nakayama
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  5. Kazuo Kawasugi
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  6. Masahide Kamakura
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  7. Tadatoshi Kinoshita
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  8. Yasushi Kuyama
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  9. Masami Yamanaka
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  10. Li-man Wang
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  11. Masaki Sanaka
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  12. Satoru Mineshita
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Yamamoto, T., Tamura, M., Hamauzu, T. et al. Intestinal Behçet's disease associated with non-Hodgkin's lymphoma. J Gastroenterol 32, 241–245 (1997). https://doi.org/10.1007/BF02936375

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  • DOI: https://doi.org/10.1007/BF02936375

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