Skip to main content

Advertisement

SpringerLink
Log in

New endoscopic treatment for chronic pancreatitis, using contrast media containing ulinastatin and prednisolone

  • Liver, Pancreas, and Biliary Tract
  • Published:
Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

The preventive effects of contrast media containing ulinastatin (UST) and/or prednisolone (PDN) on potential complications associated with endoscopic retrograde cholangiopancreatography (ERCP) were studied in 111 patients. The incidence of abdominal pain and the elevation in the serum amylase level after ERCP were lower in the UST group than in the control group and abdominal pain and the elevated serum amylase level were almost completely suppressed in the PDN and UST/PDN groups. Based on these findings, a comparative study was conducted to evaluate the effectiveness of a combination of UST and PDN, given via the pancreatic duct, in alleviating pain symptoms in 57 patients with chronic pancreatitis and abdominal pain. The post-ERCP serum amylase level in some patients in the PDN and UST/PDN groups was lower than the pretreatment value. After ERCP, the abdominal pain that had been experienced before ERCP was relieved, and the value of the bentiromide-paraaminobenzoic acid (BT-PABA) test had improved. These results suggest that the use of contrast media containing PDN or UST/PDN in patients with chronic pancreatitis is extremely effective not only for preventing potential complications related to ERCP but also as a new diagnostic treatment method.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dowsett JF, Vaira D, Polydorou A, et al. Interventional endoscopy in the pancreatobiliary tree. Am J Gastroenterol 1988;83:1328–1336.

    PubMed  CAS  Google Scholar 

  2. Cotton PB. Progress report: ERCP. Gut 1977;18:316–341.

    Article  PubMed  CAS  Google Scholar 

  3. Amman RW, Deyhle P, Butikofer E. Fatal necrotizing pancreatitis after peroral cholangiopancreatography. Gastroenterology 1973;64:320–323.

    Google Scholar 

  4. Blackwood WD, Vennes JA, Silvis SE. Post-endoscopy pancreatitis and hyperamylasuria. Gastrointest Endosc 1973;20:56–58.

    PubMed  CAS  Google Scholar 

  5. Ruppin H, Amon R, Ettl W, et al. Acute pancreatitis after endoscopic/radiological pancreaticography (ERP). Endoscopy 1974;6:94–98.

    Google Scholar 

  6. Nordback I, Airo O. Post-ERCP acute necrotizing pancreatitis. Ann Chir Gynaecol 1988;77:15–20.

    PubMed  CAS  Google Scholar 

  7. Bilbao MK, Dotter CT, Lee TG, et al. Complications of endoscopic retrograde cholangiopancreatography (ERCP): A study of 10000 cases. Gastroenterology 1979;79:314–320.

    Google Scholar 

  8. Hamilton I, Lintott DJ, Rothwell J, et al. Acute pancreatitis following endoscopic retrograde cholangiopancreatography. Clin Radiol 1983;34:543–546.

    Article  PubMed  CAS  Google Scholar 

  9. Hannigan BF, Keeling PWN, Slavin B, et al. Hyperamylasemia after ERCP with ionic and non-ionic contrast media. Gastrointest Endosc 1985;31:109–110.

    PubMed  CAS  Google Scholar 

  10. Okuno M, Himeno S, Kurokawa M, et al. Changes in serum levels of pancreatic isoamylase, lipase, trypsin and elastase 1 after endoscopic retrograde pancreatography. Hepatogastroenterology 1985;32:87–90.

    PubMed  CAS  Google Scholar 

  11. LaFerla G, Gordon B, Archibald M, et al. Hyperamylasemia and acute pancreatitis following endoscopic retrograde cholangiopancreatography. Pancreas 1986;1:160–163.

    Article  PubMed  CAS  Google Scholar 

  12. Reiertsen O, Skjoto J, Jacobsen CD, et al. Complications of fiberoptic gastrointestinal endoscopy. Endoscopy 1987;19:1–6.

    PubMed  CAS  Google Scholar 

  13. Waldron RL II, Luse SA, Wollwick HE, et al. Demonstration of a retrograde pancreatic pathway. Correlation of roentgenographic and electron microscopic studies. Am J Roentgenol Radium Ther Nucl Med 1971;111:695–699.

    PubMed  Google Scholar 

  14. Bockman DE, Schiller WR, Anderson MC. Route of retrograde flow in the exocrine pancreas during ductal hypertension. Arch Surg 1971;103:321–329.

    PubMed  CAS  Google Scholar 

  15. Barkin JS, Casal GL, Reiner DK, et al. A comparative study of contrast agents for endoscopic retrograde pancreatography. Am J Gastroenterol 1991;86:1437–1441.

    PubMed  CAS  Google Scholar 

  16. Takagi K, Ikeda S, Nakagawa Y, et al. Retrograde pancreatography and cholangiography by fiberduodenoscope. Gastroenterology 1970;59:445–452.

    PubMed  CAS  Google Scholar 

  17. Classen M, Demling L. Hazards of endoscopic retrograde cholangio-pancreaticography (ERCP). Acta Hepato-gastroenterol 1975;22:1–3.

    CAS  Google Scholar 

  18. Sand J, Nordback I. Prospective randomized trial of the effect of nifedipine on pancreatic irritation after endoscopic retrograde cholangiopancreatography. Digestion 1993;54:105–111.

    Article  PubMed  CAS  Google Scholar 

  19. Hayasaka A, Kohen H, Yoshikawa N, et al. The effect of interferon alpha and procollagen type III (PIIIP) and type IV (7-s collagen) in patients with chronic hepatitis. B. J Hepatol 1993;19:36–42.

    Article  CAS  Google Scholar 

  20. Lissoos TW, Beno DW, Davis BH. Posttranslational inhibition of Ito cell type I collagen production by triiodothyronine. Am J Physiol 1993;264:1090–1095.

    Google Scholar 

  21. Nuutinen P, Kivisaari L, Standertskjold-Nodenstam CG, et al. Microangiography of the pancreas in experimental hemorrhagic pancreatitis. Eur J Radiol 1986;6:187–190.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Bibai City Hospital, West-2, North-1, 072, Bibai, Japan

    Minoru Ohwada, Masahiro Maeda & Mikio Gotoh

  2. Department of Laboratory Diagnosis, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, 060, Sapporo, Japan

    Naoki Watanabe & Daisuke Kobayashi

  3. Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, 060, Sapporo, Japan

    Naoki Watanabe, Junko Teramoto, Hiroshi Moriya, Takaharu Nakajima, Tetsuro Okamoto, Naoki Tsuji, Daisuke Kobayashi & Yoshiro Niitsu

Authors
  1. Minoru Ohwada
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Naoki Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Masahiro Maeda
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mikio Gotoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Junko Teramoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hiroshi Moriya
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takaharu Nakajima
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Tetsuro Okamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Naoki Tsuji
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Daisuke Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yoshiro Niitsu
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ohwada, M., Watanabe, N., Maeda, M. et al. New endoscopic treatment for chronic pancreatitis, using contrast media containing ulinastatin and prednisolone. J Gastroenterol 32, 216–221 (1997). https://doi.org/10.1007/BF02936371

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02936371

Key words

Search

Navigation