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A meta-analysis of epidemiological studies on the relationship between occupational electromagnetic field exposure and the risk of adult leukemia

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Environmental Health and Preventive Medicine Aims and scope

Abstract

Since the first paper by Milham et al. suggested that occupational exposure to an electromagnetic field (EMF) could increase the risk of adult leukemia, many epidemiological studies on this problem have been published. In this report the method of meta-analysis was used to summarize the results from these papers quantitatively. The combined relative risk of all leukemia (RR=1.11), as well as acute lymphocytic leukemia (RR=1.38), acute myeloid leukemia (RR=1.07) and chronic lymphocytic leukemia (RR=1.14) increased but not significantly. So far, it is difficult to make a consistent conclusion about the relationship of the occupational exposure to EMF and adult leukemia. Further carefully designed case-control and cohort studies using the more valid means of exposure assessment are required.

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References

  1. Wertheimer N, Leeper E. Electrical wiring configurations and childhood cancer. Am J Epidemiol 1979; 109: 273–84.

    PubMed  CAS  Google Scholar 

  2. Milham S Jr. Mortality from leukemia in workers exposed to electrical and magnetic fields. N Engl J Med 1982; 307: 249.

    PubMed  Google Scholar 

  3. He J, Vupputuri S, Allen K, et al. Passive smoking and the risk of coronary heart disease - a meta-analysis of epidemiologic studies. N Engl J Med 1999; 340: 920–6.

    Article  PubMed  CAS  Google Scholar 

  4. Walter SD, Cook RJ. A comparison of several point estimators of the odds ratio in a single 2 X 2 contingency talbe. Biometrics 1991; 47: 795–811.

    Article  PubMed  CAS  Google Scholar 

  5. DeriSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177–88.

    Article  Google Scholar 

  6. Cappelleri JC, Ioannidis JP, Schmid CH, et al. Large trials vs meta-analysis of smaller trials: how do their results compare? JAMA 1996; 276: 1332–8.

    Article  PubMed  CAS  Google Scholar 

  7. Williamson D, Stroup D. EPIMETA: software for meta-analyses of epidemiologic studies. The 4th Cochrane Colloquium, Adelaide, Australia. Oct, 1996.

  8. Richardson S, Zittoun R, Bastuji-Garin S. Occupational risk factors for acute leukemia: a case-control study. Int J Epidemiol 1992; 21: 1063–73.

    Article  PubMed  CAS  Google Scholar 

  9. Savitz DA, Loomis DP. Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers. Am J Epidemiol 1995; 141: 123–34.

    Article  PubMed  CAS  Google Scholar 

  10. Flodin U, Fredriksson M, Axelson O, et al. Background radiation, electrical work, and some other exposures associated with acute myeloid leukemia in a case-referent study. Arch Environ Health 1986; 41: 77–84.

    PubMed  CAS  Google Scholar 

  11. Bastuji-Garin S, Richardson S, Zittoun R. Acute leukaemia in workers exposed to electromagnetic fields. Eur J Caner 1990; 26: 1119–20.

    CAS  Google Scholar 

  12. Miller AB, To T, Agnew DA, et al. Leukemia following occupational exposure to 60-hz electric and magnetic fields among Ontario electric utility workers. Am J Epidemiol 1996; 144: 150–60.

    PubMed  CAS  Google Scholar 

  13. Floderus B, Persson T, Stenlund C, et al. Occupational exposure to electromagnetic fields in relation to leukemia and brain tumors: a case-control study in Sweden. Cancer Causes Control 1993; 4: 465–76.

    Article  PubMed  CAS  Google Scholar 

  14. Preston-Martin S, Peters JM. Prior employment as a welder associated with the development of chronic myeloid leukaemia. Br J Cancer 1988; 58: 105–8.

    PubMed  CAS  Google Scholar 

  15. Delpizzo V. An apparently incongruous exposure-response relationship resulting from the use of job description to assess magnetic field exposure. Scand J Work Environ Health 1992; 18:242–5.

    PubMed  CAS  Google Scholar 

  16. Savitz DA, Pearce NE. Methodological issues in the epidemiology of electromagnetic fields and cancer. Epidemiol Rev 1989; 11: 59–78.

    PubMed  CAS  Google Scholar 

  17. Savitz DA, Pearce NE. Update of methodological issues in the epidemiology of electromagnetic fields and cancer. Epidemiol Rev 1993; 15: 558–66.

    PubMed  CAS  Google Scholar 

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Wang, H., Murat, Y., Nomura, S. et al. A meta-analysis of epidemiological studies on the relationship between occupational electromagnetic field exposure and the risk of adult leukemia. Environ Health Prev Med 5, 43–46 (2000). https://doi.org/10.1007/BF02935915

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  • DOI: https://doi.org/10.1007/BF02935915

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