The neuropeptide Y antagonist PYX2 decreases lordosis behavior

Thornton, Janice E.; Carson, Susan

doi:10.1007/BF02935685

Papers
Published: November 1995

The neuropeptide Y antagonist PYX2 decreases lordosis behavior

Janice E. Thornton^1,2 &
Susan Carson¹

Endocrine volume 3, pages 807–811 (1995)Cite this article

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2 Citations
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Abstract

Neuropeptide Y (NPY) has been localized to noradrenergic neurons and both the noradrenergic system and NPY play a facilitatory role in the control of luteinizing hormone-releasing hormone (LHRH) and luteinizing hormone (LH) release. The present experiments examined whether NPY also plays a role in the control of lordosis. Adult female guinea pigs were ovariectomized (ovx) and implanted with a cannula into the lateral ventricle. In Experiment 1, intracerebroventricular (ICV) administration of the NPY antagonist PYX2 (0, 0.5, 2.0 or 10.0 μg) caused a dose-dependent decrease in lordosis behavior in ovx, estrogen and progesterone-primed guinea pigs. In addition to an effect on the mean lordosis response, PYX2 also decreased the percent of animals showing lordosis and the maximum lordosis response. In Experiment 2, NPY administration (25 μg, ICV) 30 min after PYX2 (2 μg, ICV) to ovx estrogen and progesterone-primed females significantly reversed the effect of the PYX2. Because the NPY antagonist PYX2 reversibly decreased lordosis behavior this suggests that NPY plays a facilitatory role in the control of lordosis behavior.

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Neuroscience/Biopsychology Program, Oberlin College, 44074, Oberlin, Ohio, USA
Janice E. Thornton & Susan Carson
Department of Biology, Oberlin College, 44074, Oberlin, Ohio, USA
Janice E. Thornton

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Janice E. Thornton
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Thornton, J.E., Carson, S. The neuropeptide Y antagonist PYX2 decreases lordosis behavior. Endocr 3, 807–811 (1995). https://doi.org/10.1007/BF02935685

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Received: 24 July 1995
Accepted: 22 August 1995
Issue Date: November 1995
DOI: https://doi.org/10.1007/BF02935685

Keywords

Neuropeptide Y
NPY
lordosis
guinea pigs
noradrenergic
sexual behavior
PYX2
NPY antagonist