Skip to main content
SpringerLink
Log in

Estrogen attenuates expression of calcitonin-like immunoreactivity in the anterior pituitary gland

  • Papers
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Estrogens increase prolactin (PRL) synthesis and release in rats and humans, whereas pituitary-derived calcitonin-like immunoreactive peptide (pit-CT) inhibits PRL gene expression and release. To test the hypothesis that estrogens stimulate lactotrophs by diminishing pit-CT expression, the present studies examined effects of ovariectomy (ovx) and estradiol (E2) administration on (1) pit-CT IR cell population; (2) pit-CT IR content and (3) release of pit-CT IR by cultured anterior pituitary (AP) cells. Ability of anti-calcitonin immunoglobulins (anti-CT IgG) to stimulate PRL release from cultured AP cells was also examined. The results suggest that ovariectomy induced a large increase in pit-CT IR cell population in the AP gland and E2-treatment dramatically reversed this increase. Similar changes were observed in pit-CT IR content of AP extracts. Cultured AP cells from ovx rats released significantly higher amounts of pit-CT IR, and anti-CT IgG induced a significant increase in basal PRL release. AP cells from E2-treated rats secreted lower amounts of pit-CT IR and this was associated with significantly higher PRL release. These results suggest that estrogens may stimulate lactotrophs, at least in part, by removing inhibitory influence of endogenous pit-CT.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Amara, J.F., Van Itallie, C. & Dannies, P.S. (1987).Endocrinology,120, 264–271.

    PubMed  CAS  Google Scholar 

  • Barkan, A.L., Regiani, S.R., Duncan, J.A. & Marshall, J.C. (1983).Endocrinology,112, 1042–1048.

    PubMed  CAS  Google Scholar 

  • Bhatnagar, A.S., Batzl, C., Hausler, A. & Nogues, V. (1993).J. Steroid. Biochem. Mol. Biol.,47, 161–166.

    Article  PubMed  CAS  Google Scholar 

  • Castelo Branco, C., Martinez de Osaba, M.J., Vanrezc, J.A., Fortuny, A. & Gonzalez Merlo, J. (1993).Maturitas.,17, 101–111.

    Article  PubMed  CAS  Google Scholar 

  • Frank, S., Mason, H.D., Shennan, K.I.J. & Sheppard, M.C. (1984).J. Endocrinol.,103, 257–261.

    Google Scholar 

  • Giguere, B., Meunier, H., Veilleux, R. & Labrie, F. (1982).Endocrinology,111, 857–862.

    PubMed  CAS  Google Scholar 

  • Hagen, T.C., Arnout, M.A., Scherzer, W.J., Martinson, D.R. & Garthwaite, T.L. (1986).Neuroendocrinology,43, 641–645.

    Article  PubMed  CAS  Google Scholar 

  • Judd, A.M., Kubota, T., Kuan, S.I., Jarvis, W.D., Spangelo, B.L. & MacLeod, R.M. (1990).Endocrinology,127, 191–199.

    PubMed  CAS  Google Scholar 

  • Kaplan, L.M., Gabriel, S.M., Koenig, J.I., Sunday, M.E., Spindel, E.R., Martin, J.B. & Chin, W.W. (1988).Proc. Natl. Acad. Sci. USA.,85, 7408–7412.

    Article  PubMed  CAS  Google Scholar 

  • Lam, K.S.L., Srivastava, G., Lechan, R.M., Lee, T. & Reichlin, S. (1990).Neuroendocrinology,52, 417–421.

    Article  PubMed  CAS  Google Scholar 

  • Maurer, R.A. (1982).J. Biol. Chem.,257, 2133–2136.

    PubMed  CAS  Google Scholar 

  • Nagy, G., Mulchahey, J.J. & Neill, J.D. (1988).Endocrinology,122, 364–366.

    PubMed  CAS  Google Scholar 

  • Neill, J.D. (1988)The Physiology of Reproduction, edited by E. Knobil, J.D. Neill New York, NY: Raven Press. p. 1379–1393.

    Google Scholar 

  • O'Halloran, D.J., Jones, P.M., Ghatei, M.A., Domin, J. & Bloom, S.R. (1990).Endocrinology,127, 1463–1469.

    PubMed  Google Scholar 

  • Pilotte, N.S., Burt, D.R. & Barraclough, C.A. (1984).Endocrinology,124, 805–811.

    Google Scholar 

  • Potts, Jr., J.T., Aurbach, G.D. (1976).Handbook of physiology, edited by Aurbach, G.D. Washington, D.C.: American Physiological Society, p. 423–437.

    Google Scholar 

  • Prysor-Jones, R.A., Silverlight, J.J. & Jenkins, J.S. (1989).J. Endocrinol.,120, 171–177.

    Article  PubMed  CAS  Google Scholar 

  • Shah, G.V., Deftos, L.J. & Crowley, W.R. (1993).Endocrinology,132, 1367–1372.

    Article  PubMed  CAS  Google Scholar 

  • Shah, G.V., Epand, R.M. & Orlowsky, R.C. (1988).J. Endocrinol. 116, 279–286.

    PubMed  CAS  Google Scholar 

  • Shah, G.V., Kacsoh, B., Seshadri, R., Grosvenor, C.E. & Crowley, W.R. (1989).Endocrinology,125, 61–67.

    PubMed  CAS  Google Scholar 

  • Shah, G.V., Wang, W., Grosvenor, C.E. & Crowley, W.R. (1990).Endocrinology,132, 621–628.

    Google Scholar 

  • Wise, P.M., Rance, N. & Barraclough, C.A. (1981).Endocrinology,108, 2186–2192.

    PubMed  CAS  Google Scholar 

  • Woller, M.J., Campbell, G.T., Liu, L., Steigerwalt, R.W. & Blake, C.A. (1993).Endocrinology,133, 2675–2681.

    Article  PubMed  CAS  Google Scholar 

  • Wynik, D., Hammond, P.J., Akinsaya, K.O. & Bloom, S.R. (1993).Nature,364, 529–532.

    Article  Google Scholar 

  • Zamboni, L. & De Martino, C. (1967).J. Cell Biol.,35, 148A-149A.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urologic Surgery, University of Kansas Medical Center, 66160, Kansas City, Kansas, USA

    Zhuang Li & Girish V. Shah

  2. Department of Physiology, University of Kansas Medical Center, 66160, Kansas City, Kansas, USA

    Zhuang Li & Girish V. Shah

Authors
  1. Zhuang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Girish V. Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, Z., Shah, G.V. Estrogen attenuates expression of calcitonin-like immunoreactivity in the anterior pituitary gland. Endocr 3, 453–459 (1995). https://doi.org/10.1007/BF02935652

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02935652

Keywords

Search

Navigation