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T cell-mediated mechanisms in autoimmune thyroiditis

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References

  1. Weetman, A.P.; McGregor, A.M.: Autoimmune thyroid disease: developments in our understanding. Endocr. Rev.5: 309–355 (1984).

    PubMed  CAS  Google Scholar 

  2. DeBaets, M.H.: Autoimmune endocrine diseases. Concepts Immunopathol., vol. 2, pp. 1–31 (Karger, Basel 1985).

    Google Scholar 

  3. Wick G.; Möst, J.; Schauenstein, K; Krömer, G.; Dietrich H.; Ziemiecki A; Fässler R.; Schwartz, S.; Neu, N.; Hala K.: Spontaneous autoimmune thyroiditis—a bird's eye view. Immunol. Today6: 359–364 (1985).

    Article  Google Scholar 

  4. Kong, Y.M.: The mouse model of autoimmune thyroid disease; in McGregor, the immunology of endocrine diseases, pp. 1–24 (MTP Press, Lancaster 1986).

    Google Scholar 

  5. Volpé, R.: Autoimmune thyroid disease—a perspective. Mol. Biol. Med.3: 25–51 (1986).

    PubMed  Google Scholar 

  6. Pujol-Borrel, R.; Hanafusa, T. Chiovato, L.; Bottazzo, G.F.: Lectin-induced expression of DR antigens on human cultured follicular thyroid cells. Nature, Lond.304: 71–73 (1983).

    Article  Google Scholar 

  7. Londei, M.; Bottazzo, G.F.; Feldmann, M. Human T-cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells. Science228: 85–89 (1985).

    Article  PubMed  CAS  Google Scholar 

  8. Salamero, J.; Michel-Bechet, M. Charreire, J.: Expression of H-2 antigens and Thyroglobulin (Tg) on freshly dissociated and in vitro cultured monolayers of mouse thyroid epithelial cells (TEC). Tissue Antigens22: 231–238 (1983).

    Article  PubMed  CAS  Google Scholar 

  9. Lanzavecchia, A.: Antigen-specific interaction between T and B cells. Nature. Lond.314: 537–539 (1985).

    Article  PubMed  CAS  Google Scholar 

  10. Totterman, T.H.: Distribution of T-,B-and thyroglobulin-binding lymphocytes infiltrating the gland in Graves' disease, Hashimoto's thyroiditis, and de Quervain's thyroiditis. Clin. Immunol. Immunopathol.10: 270–277 (1978).

    Article  PubMed  CAS  Google Scholar 

  11. Matsushima, K.; Procopio, A.; Abe, H.; Scala, G.; Ortaldo, J.R.; Oppenheim, J.: Production of interleukin 1 activity by normal human peripheral blood B lymphocytes. J. Immun.135: 1132–1136 (1985).

    PubMed  CAS  Google Scholar 

  12. Oppenheim, J.J.; Gery, I.: Interleukin-1 is more than an interleukin. Immunol. Today3: 113–119 (1982).

    Article  CAS  Google Scholar 

  13. Rose, N.R.; Bacon, L.D.; Sundick, R.S.; Kong, Y.M.; Esquivel, P.; Bigazzi, P.E.: Genetic regulation in autoimmune thyroiditis; in Talal Autoimmunity: genetic, immunologic and clinical aspects, pp 63–87 (Academic Press, New York 1977).

    Google Scholar 

  14. Thompson, P.M.; McLachlan, S.M.; Parks, A.; Clark, F.; Howel, D.; Rees Smith, B.: The IgG subclass distribution of thyroglobulin antibody synthesized in culture. Scand. J. Immunol.18: 123–129 (1983).

    Article  PubMed  CAS  Google Scholar 

  15. Greemers, P.; Rose, N.R.; Kong, Y.M.: Experimental autoimmune thyroiditis: in vitro cytotoxic effects of T lymphocytes on thyroid monolayers. J. exp. Med.157: 559–571 (1983).

    Article  Google Scholar 

  16. Kong, Y.M.; Simon, L.L.; Creemers, P.; Rose, N.R.: In vitro T cell proliferation and cytotoxicity in murine autoimmune thyroiditis. Mount Sinai J. Med.53: 46–52 (1986).

    CAS  Google Scholar 

  17. Simon, L.L.; Justen, J.M.; Giraldo, A.A.; Krco, C.J.; Kong, Y.M.: Activation of cytotoxic T cells and effector cells in experimental autoimmune thyroiditis by shared determinants of mouse and human thyroglobulins. Clin. Immunol. Immunopathol.39: 345–356 (1986).

    Article  PubMed  CAS  Google Scholar 

  18. Maron, R.; Zerubavel, R.; Friedman, A.; Cohen, I.R.: T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice. J. Immun.131: 2316–2322 (1983).

    PubMed  CAS  Google Scholar 

  19. Braley-Mullen, H.; Johnson, M.; Sharp, G.C.; Kyriakos, M.: Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells. Cell. Immunol.93: 132–143. (1985).

    Article  PubMed  CAS  Google Scholar 

  20. Salamero, J.; Charreire, J.: Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells. VII. Generation of thyroidspecific cytotoxic effector cells. Cell. Immunol.91: 111–118 (1985).

    Article  PubMed  CAS  Google Scholar 

  21. Christadoss, P.; Kong, Y.M.; ElRehewy, M.; Rose, N.R.; David, C.S.: Genetic control of T-lymphocyte proliferative autoimmune response to thyroglobulin in mice; in Rose, Bigazzi, Warner, Genetic control of autoimmune disease, pp. 445–454 (Elsevier/North Holland, New York 1978).

    Google Scholar 

  22. Okayasu, I.; Kong, Y.M.; David, C.S.; Rose, N.R.: In vitro T-lymphocyte proliferative response to mouse thyroglobulin in experimental autoimmune thyroiditis. Cell. Immunol.61: 32–39 (1981).

    Article  PubMed  CAS  Google Scholar 

  23. Aoki, N.; De Groot, L.J.: Lymphocyte blastogenic response to human thyroglobulin in Graves' disease, Hashimoto's thyroiditis, and metastatic thyroid cancer. Clin. exp. Immunol.38: 523–530 (1979).

    PubMed  CAS  Google Scholar 

  24. Simon, L.L.; Krco, C.J.; David, C.S.; Kong, Y.M.: Characterization of the in vitro murine T-cell proliferative responses to murine and human thyroglobulins in thyroiditis-susceptible and-resistant mice. Cell. Immunol.94: 243–253 (1985).

    Article  PubMed  CAS  Google Scholar 

  25. Canonica, G.W.; Cosulich, M.E.; Croci, R.; Ferrini, S.; Bagnasco, M.; Dirienzo, W.; Ferrini, O.; Bargellesi, A.; Giordano, G.: Thyroglobulin-induced T-cell in vitro proliferation in Hashimoto's thyroiditis: indentification of the responsive subset and effect of monoclonal antibodies directed to Ia antigens. Clin. Immunol. Immunopathol.32: 132–141 (1984).

    Article  PubMed  CAS  Google Scholar 

  26. Canonica, G.W.; Caria, M.; Bagnasco, M.; Cosulich, M.E.; Giordano, G.; Moretta, L.: Proliferation of T8-positive cytolytic T lymphocytes in response to thyroglobulin in human autoimmune thyroiditis: analysis of cell interactions and culture requirements. Clin. Immunol. Immunopathol.36: 40–48 (1985).

    Article  PubMed  CAS  Google Scholar 

  27. Moretta, A.; Pantaleo, G.; Moretta, L.; Mingari, M.C.; Cerottini, J.C.: Quantitative assessment of the pool size and subset distribution of cytotoxic T lymphocytes within human resting or alloactivated peripheral blood T cell populations. J. exp. Med.158: 571–585 (1983).

    Article  PubMed  CAS  Google Scholar 

  28. Creemers, P.; Giraldo, A.A.; Rose, N.R.; Kong, Y.M.: T-cell subsets in the thyroids of mice developing autoimmune thyroiditis. Cell. Immunol.87: 692–697 (1984).

    Article  PubMed  CAS  Google Scholar 

  29. Canonica, G.W.; Caria, M; Torre, G.; Risso, A.; Cosulich, M.E.; Bagnasco, M.: Autoimmune thyroid disease: purification and phenotypic analysis of intrathyroid T cells. J. endocr. Invest.7: 641–645 (1984).

    PubMed  CAS  Google Scholar 

  30. Sakata, M.; Torisu, M.: Lymphocyte locomotion in experimental allergic thyroiditis. Clin. Immunol. Immunopathol.33: 154–164 (1984).

    Article  CAS  Google Scholar 

  31. Milanese, C.; Richardson, N.E.; Reinherz, E.L.: Identification of a T helper cell-derived lymphokine that activates resting T lymphocytes. Science231: 1118–1122 (1986).

    Article  PubMed  CAS  Google Scholar 

  32. Bagnasco, M.; Ferrini, S.; Venuti, D.; Prigione, I.; Torre, G.; Biassoni, R.; Canonica, G.W.: Clonal analysis of T lymphocytes infiltrating the thyroid gland in Hashimoto's thyroiditis. Int. Archs Allergy appl. Immun. (in press, 1986).

  33. Del Prete, G.F.; Maggi, E.; Mariotti, S.; Tiri, A.; Vercelli, D.; Parronchi, P.; Macchia, D.; Pinchera, A.; Ricci, M.; Romagnani, S.: Cytolytic T lymphocytes with natural killer activity in thyroid infiltrate of patients with Hashimoto's thyroiditis: analysis at clonal level. J. clin. Endocr. Metab.62: 52–57 (1986).

    Article  PubMed  Google Scholar 

  34. Emmrich, F.; Meuer, S.: Human T-cell clones find ever wider application. Immunol. Today6: 197–199 (1985).

    Article  Google Scholar 

  35. Moretta, A.; Pantaleo, G.; Moretta, L.; Cerottini, J.C.; Mingari, M.C.: Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity. J. exp. Med.157: 743–754 (1983).

    Article  PubMed  CAS  Google Scholar 

  36. Salamero, J.; Michel-Bechet, M.; Wietzerbin, J.; Charreire, J.: Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells (TEC). VIII. γ-Interferon induced Ia antigen expression on TEC cultures. Tissue Antigens25: 266–277 (1985).

    PubMed  CAS  Google Scholar 

  37. Todd, I.; Pujol-Borrel, R. Hammond, L.J.; Bottazzo, G.F.; Feldmann, M.: Interferon-γ induces HLA-DR expression by thyroid epithelium. Clin. exp. Immunol.61: 265–273 (1985).

    PubMed  CAS  Google Scholar 

  38. Arenzana-Seisdedos, F.; Virelizier, J.L.; Fiers, W.: Interferons as macrophage-activating factors. III. Preferential effects of interferon-γ on the interleukin 1 secretory potential of fresh or aged human monocytes. J. Immun.134: 2444–2448 (1985).

    PubMed  CAS  Google Scholar 

  39. Massa, P. T.; Dörries, R.; ter Meulen, V.: Viral particles induce Ia antigen expression on astrocytes. Nature, Lond.320: 543–546 (1986).

    Article  CAS  Google Scholar 

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Canonica, G.W., Bagnasco, M. & Kong, Yc.M. T cell-mediated mechanisms in autoimmune thyroiditis. Immunol Res 5, 305–313 (1986). https://doi.org/10.1007/BF02935503

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