Clinical and pathological observation of 106 aplastic anemia patients treated by Spatholobus suberectus composita

Abstract

Objective: To investigate the pharmaceutical effect of Spatholobus suberectus composita (SSC) on bone marrow hematopoiesis and microenvironment of aplastic anemia.Methods: One hundred and six cases of aplastic anemia patients were treated by SSC for 24 months, and the pathological changes of bone marrow of 45 patients were observed before and after treatment, and compared with those of 17 cases of normal volunteers as control.Results: The total effective rate was 77.4%. The volume of nucleated cells changed from 15.7 ± 10.2 vol % to 39.2 ± 13.9 vol%, the percentage of the granulocytes from 31.4 ± 12.4 % to 39.9 ± 10.4%), the erythroblasts from 19.8 ± 15.9% to 36.7 ± 13.5%, megakaryocytes from 1.4 ± 2.3 cell/section to 24.0 ± 24. 6 cell/section), and the microvessel number from 40.0 ± 23.4 ves/100mm² to 201.0 ± 141.0 ves/100mm²), all the criteria increased significantly (P < 0.01 orP < 0. 05).Conclusion: SSC could not only irritate the hematopoiesis, but also exert reconstructive action to marrow microenvironment.