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Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract

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Abstract

Objective: To investigate the role of endothelin-1 (ET-1) in development of ischemic brain damage after subarachnoid hemorrhage (SAH), and the protective effect of Ginkgo biloba extract (GBE) on it.Methods: Noncraniotomy SAH models of Wistar rat were divided into SAH group and GBE treated group, the diameter of basilar artery (BA), dynamic changes of regional cerebral blood flow (rCBF) and ET-1 content of in-tracranial plasma within 24 hours after SAH of both groups were determined. And pathological examination of CA1 region of hippocampus was performed 3 days later.Results: rCBF decreased and ET-1 content increased obviously and steadily in 24 hours after SAH. Spasm of BA occurred half an hour after SAH and neurons of hippocampus CA1 region were damaged severely. GBE could antagonize the above-mentioned pathological changes effectively

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Baoliang, S., Zuoli, X., Chengbi, Z. et al. Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract. CJIM 5, 279–282 (1999). https://doi.org/10.1007/BF02935404

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  • DOI: https://doi.org/10.1007/BF02935404

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