Abstract
Objective: A comparative study on immunologic effects of Composite Prescription in Mice. Methods:
Youguiyin prescription for tonifying Kidney), Sijunzi Decoction (
for invigorating Spleen) and Taohong Siwu Decoction (
for promoting blood circulation) were conducted in mice aged 18 months and divided into 4 groups. The above-mentioned prescriptions were given to group I - III respectively. Group IV was kept untreated for aged control. Another group of 3 month-old mice was selected as the adult control. Results: T-, B-lymphocyte transformation rate and OKT3 lymphocyte, subgroup in the aged control group were distinctly lower than those in the adult control group. After 4 weeks treatment with different composite prescriptions, the T-, B-lymphocyte transformation rate of group II and III were evidently higher than those of the aged control group and OKT3 lymphocyte subgroup was distinctly lower in group I than that of group IV.Conclusions: The prescription of tonifying Kidney acted on immunal function of aged animals in a way different from that of prescriptions for invigorating Spleen or for promoting blood circulation.
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References
Meites J. Neuroendocrine biomarkers of aging in the rat. Experimental Gerontology 1988; 23: 349–358.
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Zhang, XM., Shen, ZY., Wang, WJ. et al. Comparative study on immunologic effect of Composite Prescriptions of tonifying kidney, invigorating Spleen and promoting blood circulation drugs in mice. CJIM 3, 123–126 (1997). https://doi.org/10.1007/BF02935370
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DOI: https://doi.org/10.1007/BF02935370