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A study on protective action of Astragalus Injection()in ouabain-induced cardiac Toxicity of guinea pigs)in ouabain-induced cardiac Toxicity of guinea pigs

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Abstract

Objective: To study the protective action of Astragalus Injection (AI) on ouabain-induced cardiac toxicity.Methods: Forty guinea-pigs were randomly divided into the AI group and the control group, AI injected intravenously in the AI group and 0.9% normal saline injected in the control group, ouabain was injected in contralateral of both groups intravenously 8 mins later. The time of cardiac ventricular tachycardia (VT) and cardiac ventricular fibrillation (VF), and the dose of ouabain were documented.Results: Compared with the control group AI could markedly prolong the time of VT and VF, and increase the dose of ouabain induces VT and VF (P < 0.01).Conclusion: AI decreases the incidence of digitalism.

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Authors and Affiliations

  1. Cardiovascular Department, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine and Pharmacology, 510405, Guangzhou

    Zhong-qi Yang, Shao-xiang Xian, Ming-ping Liu, Qian-wei Chen, Hui-ping Zheng & Li-cheng Zhao

Authors
  1. Zhong-qi Yang
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  2. Shao-xiang Xian
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  3. Ming-ping Liu
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  4. Qian-wei Chen
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  5. Hui-ping Zheng
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  6. Li-cheng Zhao
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Corresponding author

Correspondence to Zhong-qi Yang.

Additional information

This subject is supported by the Scientific Research Fund of Guangzhou University of Traditional Chinese Medicine and Pharmacology (No. 9764)

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Yang, Zq., Xian, Sx., Liu, Mp. et al. A study on protective action of Astragalus Injection()in ouabain-induced cardiac Toxicity of guinea pigs)in ouabain-induced cardiac Toxicity of guinea pigs. CJIM 7, 48–49 (2001). https://doi.org/10.1007/BF02935112

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  • DOI: https://doi.org/10.1007/BF02935112

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