Abstract
Objective: To observe the therapeutic effect on hepatic fibrosis of chronic hepatitis B by Chinese medicine—Handan Ganle capsule (HDGLC).Methods: A total of 104 patients with chronic hepatitis B has been treated by HDGLC for 6 months, liver fibrosis indexes and the serum biochemical indexes were detected before treatment, during the curative period and by the end of treatment. Hepatic biopsy was performed before or after the treatment.Results: The improvement rate of clinical symptoms was 79.0% - 90.6%, and the recovery rate of ALT was 72.6 %, serum fibrosis indexes such as HA, type IV collagen and LN were significantly decreased along with the extending course of disease (P < 0.05). The pathohistological score of liver was decreased from 7.82 ± 6.22 before treatment to 5.16 ± 3.75 after treatment (P < 0.05) and the score of hepatic fibrosis was decreased from 7.49 ± 5.45 before treatment to 5.16 ± 4.26 after treatment (P < 0.05).Conclusion: HDGLC has remarkable therapeutic and reversing effect on chronic hepatitis B induced hepatic fibrosis.
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References
Cheng ML, Liu SD. The basic study and clinical practice on hepatic fibrosis. 1st, edition. Beijing: People’ s Health Publishing House, 1996:228–258.
Conference on Infectious Disease and Parasitic Disease of Chinese Medical Association. Prevention and treatment program on viral hepatitis (provisional). Chin J Infec Dis 1995; 13:241–247.
Knodell KG, Ishak KG. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 431–435.
Chwvallire M, Guerret S. A histological semi-quantitative scoring system for evaluation of hepatic fibrosis in needle liver biopsy specimens-comparison with morphormetive studies. Hepatology 1992; 22:349–355.
Li W, Dai QT, Liu ZE, et al. The primary observation on early hepatic fibrosis of chronic hepatitis B treated by Gingko biloba granule. CJITWM 1995; 15(10): 593–595.
Ma H, Wang BE, Chen YY, et al. The experimental study of treatment effect of the milkvetch on hepatic fibrosis. Chin J Hepatology 1997; 5(1): 32.
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Supported by the Key Project of the “9th Five Year Plan” of Science Commission of Guizhou Province
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Cheng, Ml., Lu, Yy., Wu, J. et al. Clinical study on reversing hepatic fibrosis with Handan Ganle () capsule) capsule. CJIM 7, 16–18 (2001). https://doi.org/10.1007/BF02935100
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DOI: https://doi.org/10.1007/BF02935100