Effects of Xianzhen tablet on Na⁺ - K⁺ - ATPase and Ca²⁺ - Mg²⁺ - ATPase in erythrocytic membranes and viscosity of whole blood in non-insulin-dependent diabetes patients with Qi-Yin deficiency, Kidney deficiency and blood stasis

Abstract

Objective: To assess the effects of Xianzhen tablet (XZT) on Na⁺-K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase on erythrocytic membranes, viscosity of whole blood, plasma glucose and clinical manifestations.Methods: Seventy-two cases of non-insulin-dependent diabetes mellitus (NIDDM) patients with deficiency of both Qi and Yin, deficiency of the Kidney and blood stasis were selected, and the effects of treatment on Na⁺ K⁺ -ATPase, Ca²⁺-Mg²⁺-ATPase, whole blood viscosity, blood sugar and clinical symptoms were observed.Results: In XZT group (test group), activities of Na⁺ -K⁺ -ATPase and Ca²⁺ -Mg²⁺ -ATPase rose significantly (P < 0.01,P < 0.05) after treatment. Viscosity of whole blood and clinical manifestations also improved obviously. The total effective rate in lowering plasma glucose was 77.8% with fasting blood glucose (FBG) and 69. 4% with 2 hours postprandial plasma blood glucose (2°PBG). In the control group, viscosity of whole blood and clinical manifestations had no significant improvement. Its total effective rate in lowering plasma glucose was 41.7% with FBG and 38.9% with 2°PBG.Conclusions: XZT played a certain role in increasing activities of Na⁺ -K⁺ -ATPase and Ca²⁺ -Mg²⁺ -ATPase, decreasing viscosity of whole blood and plasma glucose and improving clinical manifestations. Therefore, XZT was experimentally manifested as an effective drug in treating NIDDM patients with Qi-Yin deficiency, renal deficiency and blood stasis.