Clinical biochemical observation on the treatment of postmenopausal osteoporosis with Gusong II

Abstract

Objective: To assess the effect of Gusong II in treating postmenopausal osteoporosis and try to reveal its mechanism.Methods: Thirty-five women, 49 to 62 years old, with 5.6 years menopause, were treated as the subjects and followed-up for 6 months, 12 months or 24 months. The course of treatment ranged from 6 months to 25 months with an average of 14 months. Some related biochemical parameters, such as serum estradiol (E₂), testosterone (T), the ratio of fasting urinary calcium to creatinine (Ca/Cr), the ratio of 24h urinary calcium to creatinine (24h Ca/Cr), 24h urinary E₂, and 24h urinary hydroxyproline (HOP) were measured before and after treatment.Results: After 6~9 months or 1~2 years of treatment, the levels of serum E₂ and 24h urinary E₂ were raised significantly, while the levels of serum T and urinary Ca/Cr fell evidently after one or two year’s treatment. The levels of serum E₂ and 24h urinary E₂ were significantly correlated with the levels of fasting urinary Ca/Cr, 24h urinary Ca/Cr, serum T, and 24h urinary HOP respectively.Conclusions: Gusong-II can elevate the serum E₂ levels of postmenopausal women, reduce the discharge of urinary calcium and HOP, and inhibit bone resorption. The rise of the serum E₂ level might be correlated with the conversion of T to E₂.