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Study on the effect of Chinese herbal medicine in regulating peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis

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Abstract

Objective: To observe the regulating effect of Chinese herbal medicine on peritoneal lymphatic stomata and its significance in treating ascites in liver fibrosis model mice.Methods: Two Chinese herbal compound prescriptions were used separately to treat the carbon tetrachloride induced mouse model of liver fibrosis, the histo-pathologic changes in mice were observed by using scanning electron microscope and processed by computer image processing. The changes of urinary volume and sodium ion concentration were measured, too.Results: In the treated group, the histo-pathologic changes were significantly less than those in the control group, the peritoneal lymphatic stomata enlarged with increased number of opening and higher density in distribution and the urinary volume and sodium ion excretion increased after treatment.Conclusion: Chinese herbal medicine has marked effect in alleviating liver fibrosis, regulating peritoneal lymphatic stomata, improving the drainage of ascites from peritoneal cavity, causing increase of urinary volume and sodium ion excretion to reduce water and sodium retention, and thus have favorable therapeutic effect in treating ascites.

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Authors and Affiliations

  1. Division of Lymphology, Department of Histology and Embryology, Medical School of Zhejiang University, 310006, Hangzhou

    Ji-cheng LI, Shu-hui Yuan, Jian-pei Zhao & Zhi-liang Lu

Authors
  1. Ji-cheng LI
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  2. Shu-hui Yuan
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  3. Jian-pei Zhao
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  4. Zhi-liang Lu
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Corresponding author

Correspondence to Ji-cheng LI.

Additional information

This article was funded by the National Foundation of Natural Sciences (No.39970934), fund for Scientific Researches by Science Committee of Hangzhou, fund for focal projects by State Administration of TCM (No. 972031), funded by Zhejiang Provincial Administration of TCM, special fund for excellent young talented person by Ministry of Health, and Analysis and Testing fund of Zhejiang Province

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LI, Jc., Yuan, Sh., Zhao, Jp. et al. Study on the effect of Chinese herbal medicine in regulating peritoneal lymphatic stomata and enhancing drainage of ascites in mice with liver fibrosis. CJIM 7, 121–125 (2001). https://doi.org/10.1007/BF02935019

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  • DOI: https://doi.org/10.1007/BF02935019

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