Abstract
Objective: To observe the clinical effect of Modified Taohong Siwu Decoction (MTSD) in treating pediatric intractable nephropathy (PIN).Methods: Ninety-five patients with PIN were divided into 2 groups at random. The 60 patients in the treated group were treated with MTSD and the 35 patients in the control group were treated with heparin. The clinical therapeutic effect and levels of thromboxane B2(TXB2) and 6-keto-prostacyclin Fla(6-keto-PGFla) before and after treatment were observed. Results: The total effective rate in the treated group was 81.7%, which was similar to that in the control group (80.0%,P > 0.05). The levels of TXB2 and TXB2/6-keto-PGFla ratio were higher in both groups of the patients as compared with those of the healthy control (P<0.01). After treatment, the two criteria were significantly improved in the two treated groups, as compared with those before treatment, the difference was significant (P<0.01), while in comparison between the MTSD treated group and the control group, no significant difference was found (P >0. 05).Conclusion: MTSD has good effect in treating PIN, it could improve the metabolic unbalance of thromboxane and prostacyclin.
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References
Li Hy, Sun Fe, Wang H, et al. Treatment of primary nephrotic syndrome with hyper-viscosity of blood by leech. Chin J Pediat 1995;33(1):28–30.
Chen Gt, Yang Ss, Fang Dy, et al. Practical Integrated Traditional Chinese and Western Medical Diagnostics and Therapeutics. Beijing: Chin Publishing House of Med Sci & Tech 1991:1117–1118.
Li H. Study on TXA2 and PGI2 levels and blood stasis syndrome and activating blood circulation to remove stasis. CJIM(Chin) 1995;15(11):701–702.
Li Hx, Zhang Jy, Xia W, et al. Effect and clinical significance of heparin therapy on platelet activation in patients of glomerular nephritis. Chin J of Nephrology 1999; 15(6): 380–381.
Wei Jx, Lu Ry, Yu Cl, et al. Progression of Application of Chinese Weil-Known Recipes. Beijing: Chin Publishing House of Med Sci & Tech 1991: 272–275.
Chen Kj, Zhang Zn, Liang Zj, et al. Studies of Blood Stasis Syndrome and Activating Blood Circulation to Remove Stasis. Shanghai: Shanghai Publishing House of Sci & Tech 1990:515–548.
Wang Y, Wang Yz, Ma Hy, et al. Practical Clinical Hemorrheology. Beijing: Xueyuan Publishing House 1994: 239–275.
Zhourx, Kongjs. Clinical observation on treatment of 34 cases of adult primary nephrotic syndrome type II by integrated Chinese and western medicine. CJIM(Chin) 1997; 17(4):236–237.
Li Yj, Ye Rg, Jiang T, et al. Study on treatment of primary nephrotic syndrome. Chin J Nephrology 1995; 11(3):133–134.
Chen Sh, Ye Rg, Li Hq. Clinical observation on treatment of nephritic nephrosis with integrated Chinese and western medicine. Chin J of Nephrology 1995; 11(6):357–358.
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Yu, Ky., Huang, Xh., Li, WL. et al. Clinical observation on treatment of pediatric intractable nephropathy with modified Taohong Siwu decoction (). CJIM 7, 94–98 (2001). https://doi.org/10.1007/BF02935010
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DOI: https://doi.org/10.1007/BF02935010