Medical Oncology and Tumor Pharmacotherapy

, Volume 3, Issue 2, pp 111–118 | Cite as

Modulation of the effects of fluoropyrimidines on toxicity and tumor inhibition in rodents by uridine and thymidine

  • Hans Rudolf Hartmann
  • Werner Bollag


Uridine and/or thymidine were administered concomitantly with 5-fluorouracil (5-FU) and 5′-deoxy-5-fluorouridine (5′-dFUR) to mice and rats in order to establish whether the physiological nucleosides actingin vitro as antagonists can diminish fluoropyrimidine toxicityin vivo. In addition, the influence of orally co-administered uridine on antitumor activity of 5-FU and 5′-dFUR in mice has been studied. All co-administrations aggravated the general toxicity of both fluoropyrimidines. Tumor inhibition was enhanced by uridine, but the therapeutic ratio was not improved compared to monotherapy with either 5-FU or 5′-dFUR.

Key words

Fluoropyrimidines Uridine Toxicity Tumor inhibition 


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Copyright information

© Humana Press Inc. 1986

Authors and Affiliations

  • Hans Rudolf Hartmann
    • 1
  • Werner Bollag
    • 1
  1. 1.Pharmaceutical ResearchF. Hoffmann-La Roche & Co. Ltd.BasleSwitzerland

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