The effect of 5-fluorouracil on rat adrenal function

  • D. J. Kerr
  • A. D. Burt
  • G. H. Beastall
  • C. D. Holloway


This study was undertaken to determine the effects of 5-fluorouracil on corticosteroidogenesis and adrenal size in the rat. The rats were injected intraperitoneally with 5-FU (12.5 mg kg−1 or 25 mg kg−1), normal saline or actinomycin D (0.02 mg kg−1), daily for 10 days. High-dose 5-FU induces adrenal hyperplasia, in association with mild impairment of corticosteroidogenesis (manifest by lower corticosterone and higher ACTH levels). The response to low-dose 5-FU and actinomycin D is of lesser adrenal hyperplasia, relative to high-dose 5-FU (P<0.05) and elevated corticosterone levels. There may be a dose-related effect on the suppression of corticosteroidogenesis in the rat by 5-FU.

Key words

5-Fluorouracil Corticosterone ACTH 


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Copyright information

© Humana Press Inc. 1986

Authors and Affiliations

  • D. J. Kerr
    • 1
  • A. D. Burt
    • 2
  • G. H. Beastall
    • 4
  • C. D. Holloway
    • 3
  1. 1.Department of Medical OncologyGlasgow UniversityGlasgowU.K.
  2. 2.Department of PathologyWestern InfirmaryGlasgowU.K.
  3. 3.MRC Blood Pressure UnitWestern InfirmaryGlasgowU.K.
  4. 4.Department of Clinical ChemistryGlasgow Royal InfirmaryGlasgowU.K.

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