Towards the reduction of lung cancer

  • Ernst L. Wynder
Chemical Cancer Risks


The epidemiology of lung cancer clearly demonstrates the preventive opportunities that exist for major causes of cancer death. We have the opportunity to affect lung cancer rates by reducing the effects of smoking. Such activities, in increasing order of importance, include low-yield cigarettes, tobacco smoking cessation and tobacco smoking prevention. Within a community these activities could best be conducted and carried out through a Disease Prevention Unit (DPU), the nature of which is briefly described in this paper.

Key words

Lung cancer Smoking Prevention Air pollution 


  1. 1.
    Soemmering S T:De morbis vasorum absorbentium corporis humanae. Frankfurt, Germany, Varrentrapii et Wenneri (1795).Google Scholar
  2. 2.
    Abbe R: Cancer of the mouth. The case against tobacco.NY Med J 102, 1 (1915).Google Scholar
  3. 3.
    Mueller F H: Tabakmissbrauch und Lungencarcinom.Z Krebsforsch 49, 57 (1939).Google Scholar
  4. 4.
    Wynder E L, Graham E A: Tobacco smoking as a possible risk factor in bronchiogenic carcinoma. A study of six hundred and eighty-four proved cases.J Am Med Ass 143, 329 (1950). (Republihhed as a Landmark article,J Am Med Ass 253, 2986, (1985).Google Scholar
  5. 5.
    Doll R, Hill A B: Smoking and carcinoma of the lung. Preliminary report.Br Med J 2, 739 (1950).PubMedGoogle Scholar
  6. 6.
    Doll R, Hill A B: A study of the aetiology of carcinoma of the lung.Br Med J 2, 1272 (1952).Google Scholar
  7. 7.
    Doll R, Hill A B: The mortality of doctors in relation to their smoking habit; a preliminary report.Br Med J 1, 1451 (1954).PubMedGoogle Scholar
  8. 8.
    Doll R, Hill A B: Lung cancer and other causes of death in relation to smoking. A second report on the mortality of British doctors.Br Med J 2, 1071 (1956).PubMedGoogle Scholar
  9. 9.
    Best E W, Josie G H,et al.: A Canadian study of mortality in relation to smoking habits. A preliminary report.Can J publ Hlth 52, 99 (1961).Google Scholar
  10. 10.
    Hammond E C, Horn D: Smoking and death rates— report on fifty-four months of follow-up on 187,783 men.J Am Med Ass 166, 1159 (1958).Google Scholar
  11. 11.
    Dorn H F: The mortality of smokers and nonsmokers.Proceedings of the Social Statistic Section of the American Statistical Association, Annual meeting of the American Statistical Association, Chicago, IL, December 27–30, 1958, pp. 34–71. Washington, DC, American Statistical Association (1959).Google Scholar
  12. 12.
    Wynder E L, Graham E A, Croninger A B: Experimental production of carcinoma with cigarette tar.Cancer Res 13, 855 (1953).PubMedGoogle Scholar
  13. 13.
    Graham E A, Croninger A B, Wynder E L: Experimental production of carcinoma with cigarette tar. IV. Successful experiments with rabbits.Cancer Res 17, 1058 (1957).PubMedGoogle Scholar
  14. 14.
    Wynder E L, Wright G: A study of tobacco carcinogenesis. I. The primary fractions.Cancer 10, 255 (1957).PubMedCrossRefGoogle Scholar
  15. 15.
    Wynder E L, Hoffman D: Tobacco and tobacco smoke.Studies in Experimental Carcinogenesis. New York, Academic Press (1967).Google Scholar
  16. 16.
    Royal College of Physicians:Smoking and Health. London, Pitman Medical (1962).Google Scholar
  17. 17.
    U.S. Public Health Service:Smoking and Health. Report of the Advisory Committee to the Surgeon General of the U.S. Public Health Service. U.S. Public Health Service Publ. No. 1103 (1964).Google Scholar
  18. 18.
    Hoffmann D, Wynder E L: A study of tobacco carcinogenesis. XXX. Chemical constituents and bioactivity of tobacco smoke. IARC Scientific Publication74, 145 (1986).Google Scholar
  19. 19.
    Hecht S S, Amin S, Melikian A A, LaVoie E J, Hoffmann D: Effects of methyl and fluorene substitution on the metabolic activation and tumorigenicity of polycyclic aromatic hydrocarbons.Am chem Soc symp Ser 238, 85 (1985).Google Scholar
  20. 20.
    Hoffmann D, Hecht S S: Perspectives in cancer research.Cancer Res 45, 935 (1985).PubMedGoogle Scholar
  21. 21.
    Hoffmann D, Harris C C (eds):Mechanisms in Tobacco Carcinogenesis. Banbury Report 23. Cold Spring Harbor NY, Cold Spring Harbor Laboratories (1986).Google Scholar
  22. 22.
    Wynder E L, Hammond E C: A study of air pollution carcinogenesis. I. Analysis of epidemiological evidence.Cancer 15, 79 (1962).PubMedCrossRefGoogle Scholar
  23. 23.
    Hall N E L, Wynder E L: Diesel exhaust exposure and lung cancer: a case-control study.Envir Res 34, 77 (1984).CrossRefGoogle Scholar
  24. 24.
    Wynder E L, Higgins I T T, Gordis L (eds): Workshop Report: workshop on guidelines to the epidemiology of weak associations.Prev Med 16, 139 (1987).Google Scholar
  25. 25.
    Schenker M B, Smith T, Munos A, Woske S, Speizer F E:Br J ind Med 41, 320 (1984).PubMedGoogle Scholar
  26. 26.
    Wynder E L, Higgins I T T: Exposure to diesel exhaust emissions and the risk of lung and bladder cancer, in Ishinishi N, Koizumi A, McClellan R O, Stoeber W (eds):Carcinogenic and Mutagenic Effects of Diesel Engine Exhaust, pp. 489–501. New York, Elsevier (1986).Google Scholar
  27. 27.
    U.S. Department of Health and Human Services: The Health Consequences of Smoking. Environmental Tobacco Smoke. Report of the Surgeon General, U.S. Department of Health and Human Services, Office on Smoking and Health. Washington DC. U.S. Superintendent of Documents (1986).Google Scholar
  28. 28.
    Wynder E L, Hebert J R, Kabat G C: Association of dietary fat and lung cancer.J natn Cancer Inst 79, 677 (1987).Google Scholar
  29. 29.
    Beems R B, Van Beek L. Modifying effect of dietary fat on benzo(a)pyrene-induced respiratory tract tumor in hamsters.Carcinogenesis 5, 413 (1984).PubMedCrossRefGoogle Scholar
  30. 30.
    Hoffmann D, T'So T C, Gori G B: The less harmful cigarette.Prev Med 9, 287 (1980).PubMedCrossRefGoogle Scholar
  31. 31.
    Kabat G C, Wynder E L: Determinants of quiting smoking.Am J publ Hlth 77, 1301 (1987).CrossRefGoogle Scholar
  32. 32.
    Kaufman D W, Helmrich S P, Rosenberg L, Miettenen O S, Shapiro S: Nicotine and carbon monoxide content of cigarette smoke and the risk of myocardial infarction in young men.New Engl J Med 308, 409 (1983).PubMedGoogle Scholar
  33. 33.
    Koop C E: The quest for a smoke-free young America by the year 2000.J Sch Hlth 56, 8 (1986).Google Scholar
  34. 34.
    National Cancer Institute, Div Cancer Prevention and Control: 1986 Annual Cancer Statistics Review. NIH Publ. No. 87-2789. Bethesda, MD, National Cancer Institute (1987).Google Scholar

Copyright information

© Pergamon Press Ltd. 1987

Authors and Affiliations

  • Ernst L. Wynder
    • 1
  1. 1.American Health FoundationNew YorkU.S.A.

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