Medical Oncology and Tumor Pharmacotherapy

, Volume 4, Issue 3–4, pp 187–192 | Cite as

Papillomaviruses in human genital cancer

  • Harald Zur Hausen
Viruses and Cancer Risks


Cervical Cancer Genital Wart Penile Cancer Epidermodysplasia Verruciformis Laryngeal Papillomatosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    zur Hausen H, Schneider A: The role of papillomaviruses in human anogential cancer, in Howley P M, Salzmann N P (eds):The Papillomaviruses (in press).Google Scholar
  2. 2.
    Pfister H: Biology and biochemistry of papillomaviruses.Rev physiol biochem Pharmac 99, 111 (1984).CrossRefGoogle Scholar
  3. 3.
    Schiller J T, Vaas W C, Lowry D R: Identification of a second transforming region in bovine papillomavirus DNA.Proc natn Acad Sci U.S.A. 82, 7880 (1984).CrossRefGoogle Scholar
  4. 4.
    Yang Y C, Okayama H, Howley P M: Bovine papillomavirus contains multiple transforming genes.Proc natn Acad Sci U.S.A. 82, 1030 (1985).CrossRefGoogle Scholar
  5. 5.
    Lusky M, Botchan M R: Characterization of the bovine papillomavirus plasmid maintenance sequences.Cell 36, 391 (1984).PubMedCrossRefGoogle Scholar
  6. 6.
    zur Hausen H: Evidence for an association between human papillomaviruses and neoplasia.Int Med 7, 66 (1986).CrossRefGoogle Scholar
  7. 7.
    Dartmann K, Schwarz E, Gissmann L, zur Hausen H: The nucleotide sequence and genome organization of human papillomavirus type 11.Virology 151, 124 (1986).PubMedCrossRefGoogle Scholar
  8. 8.
    Boshart M, zur Hausen H: Human papillomaviruses (HPV) in Buscke-Löwenstein tumors: physical state of the DNA and identification of a tendem duplication in the non-coding region of a HPV-6 subtype.J. Virol (1958, 963 (1986).Google Scholar
  9. 9.
    de Villiers E-M, Neumann C, Le J-Y, Weidauer H, zur Hausen H: Infection of the oral mucosa with defined types of human papillomaviruses.Med Microbiol. Immun 174, 287 (1986).CrossRefGoogle Scholar
  10. 10.
    Gissmann L, Diehl V, Schultz-Coulon H-J, zur Hausen H: Molecular cloning and characterization of human papillomavirus DNA derived from a laryngeal papilloma.J Virol 44, 393 (1982).PubMedGoogle Scholar
  11. 11.
    Mounts P, Shah K V, Kashima H: Viral etiology of juvenile and adult onset squamous papilloma of the larynx.Proc natn Acad Sci U.S.A. 79, 5425 (1982).CrossRefGoogle Scholar
  12. 12.
    Kreider J W, Howett M K, Wolfe S A, Bartlett G L, Zaino R J, Sedlacek T V, Mortel R: Morphological transformationin vivo of human uterine cervix with papillomavirus from condylomata acuminata.Nature 317, 639 (1985).PubMedCrossRefGoogle Scholar
  13. 13.
    Yasumoto S, Burkhardt A L, Doniger J, DiPaolo J A: Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells.J Virol 57, 572 (1986).PubMedGoogle Scholar
  14. 14.
    Dürst M, Dzarlieva-Petrusevzka R T, Boukamp P, Fusenig N, Gissmann L: Transfection of primary human foreskin keratinocytes with human papillomavirus (HPV) type 16 DNA leads to escape from senescence.Oncogene (in press).Google Scholar
  15. 15.
    de Villiers E-M, Wagner D, Schneider A, Wesch H, Miklaw H, Wahrendorf J, Papendick U, zur Hausen H: Human papillomavirus infections in women without and with abnormal cervical cytology.Lancet (in press).Google Scholar
  16. 16.
    Dürst M, Gissmann L, Ikenberg H, zur Hausen H: A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.Proc natn Acad Sci U.S.A. 80, 3812 (1983).CrossRefGoogle Scholar
  17. 17.
    Boshart M, Gaissmann L, Ikenberg H, Kleinheinz A, Scheurlen W, zur Hausen H: A new type of papillomavirus DUA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.EMBO J 3, 1151 (1984).PubMedGoogle Scholar
  18. 18.
    Scholl S M, Pillers E M, Robinson R E, Farrell P J: Prevalence of human papillomavirus type 16 DNA in cervical carcinoma samples in East Anglia.Int J Cancer 35, 215 (1985).PubMedCrossRefGoogle Scholar
  19. 19.
    Gissmann L, Wolnik H, Ikenberg H, Koldovsky U, Schnürch H G, zur Hausen H: Human papillomavirus type 6 and 11 sequences in genital and laryngeal papillomas and in some cervical cancers.Proc natn Acad Sci U.S.A. 80, 560 (1983).CrossRefGoogle Scholar
  20. 20.
    Beaudenon S, Kremsdorf D, Croissant O, Jablonska S, Wain-Hobson S, Orth G: A novel type of human papillomavirus associated with genital neoplasias.Nature 321, 246 (1986).PubMedCrossRefGoogle Scholar
  21. 21.
    Beckmann A M, Daling J R, McDougall J K: Human papillomavirus DNA in anogenital carcinomas.J. cell Biochem (Suppl.)9c, 68 (1985).Google Scholar
  22. 22.
    Schwarz E, Freese U K, Gissmann L, Mayer W, Roggenbuck B, Stremlau A, zur Hausen H: Structure and transcription of human papillomavirus sequences in cervical carcinoma cells.Nature 314, 111 (1985).PubMedCrossRefGoogle Scholar
  23. 23.
    Yee, C, Krishnan-Howlett I, Baker C C, Schlegel R, Howley P M: Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.Am J Path 119, 361 (1985).PubMedGoogle Scholar
  24. 24.
    Pater M M, Pater A: Human papillomavirus types 16 and 18 sequences in carcinoma cell lines of the cervix.Virology 145, 313 (1985).PubMedCrossRefGoogle Scholar
  25. 25.
    Dürst M, Kleinheinz A, Hotz M, Gissmann L: The physical state of human papillomavirus type 16 DNA in benign and malignant tumors.J gen Virol 66, 1515 (1985).PubMedCrossRefGoogle Scholar
  26. 26.
    Mincheva A, Gissmann L, zur Hausen H: Chromosomal integration sites of human papillomavirus DNA in three cervical cancer cell lines mapped byin situ hybridization.Med microbiol Immun (in press).Google Scholar
  27. 27.
    Spalholz B A, Yang Y-C, Howley P M: Transactivation of a bovine papillomavirus transcriptional regulatory element by the E2 gene product.Cell 42, 183 (1985).PubMedCrossRefGoogle Scholar
  28. 28.
    Crum C P, Mitao M, Levine R U, Silverstein S: Cervical papillomavirus segregates within morphologically distinct precancerous lesions.J Virol 54, 675 (1985).PubMedGoogle Scholar
  29. 29.
    de Villiers E-M, Weidauer H, Otto H, zur Hausen H: Papillomavirus DNA in human tongue carcinomas.Int J Cancer 36, 575 (1985).PubMedCrossRefGoogle Scholar
  30. 30.
    Ikenberg H, Gissmann L, Gross G, Grussendorf E-I, zur Hausen H: Human papillomavirus type 16-related DNA in genital Bowen's disease and in Bowenoid papulosis.Int J Cancer 32, 563 (1983).PubMedCrossRefGoogle Scholar
  31. 31.
    Kahn T, Schwarz E, zur Hausen H: Molecular cloning and characterizations of the DNA of a new human papillomavirus (HPV 30) from a laryngeal carcinoma,Int J Cancer 37, 61 (1986).PubMedCrossRefGoogle Scholar
  32. 32.
    Löning T, Ikenberg H, Becker J, Gissmann L, Hoepfer I, zur Hausen H: Analysis of oral papillomas, leukoplakias and invasive carcinomas for human papillomavirus related DNA.J invest Derm 84, 417 (1985).PubMedCrossRefGoogle Scholar
  33. 33.
    Lorincz A T, Lancaster W D, Temple G F: Detection and characterization of a new type of human papillomavirus.J cell Biochem (Suppl.)9c, 75 (1985).Google Scholar
  34. 34.
    Orth G, Favre M, Breitburd F, Croissant O, Jablonska S, Obalek M, Jarzabek-Chrozelska M, Rzesa G: Epidermodysplasia verruciformis: a model for the role of papillomaviruses in human cancer, in Essex M, Todaro G, zur Hausen H (eds.):Viruses in Naturally Occurring Cancers, pp. 259–282. Cold Spring Harbor NY, Cold Spring Harbor Laboratories Press (1980).Google Scholar
  35. 35.
    Scheurlen W, Stremlau A, Gissmann L, Höhn D, Zehner H-P, zur Hausen H: Rearranged HPV 16 molecules in an anal carcinoma and in a laryngeal carcinoma.Int J Cancer (in press).Google Scholar
  36. 36.
    Stremlau A, Gissmann L, Ikenberg H, Stark M, Bannasch P, zur Hausen H: Human papillomavirus type 16-related DNA in an anaplastic carcinoma of the lung.Cancer 55, 737 (1985).CrossRefGoogle Scholar
  37. 37.
    Tsunokawa Y, Takebe N, Kasamatsu Y, Terada M, Sugimura T: Transforming activity of human papillomavirus type 16 DNA sequences in a cervical cancer.Proc natn Acad Sci U.S.A. 83, 2200 (1986).CrossRefGoogle Scholar
  38. 38.
    zur Hausen H: Human papillomavirus and their possible role in squamous cell carcinomas.Curr Topics Microbiol Immun 78, (1977).Google Scholar
  39. 39.
    zur Hausen H: Human genital cancer: synergism between two virus infections or between a virus infection and initiating events.Lancet 2, 1370 (1982).PubMedCrossRefGoogle Scholar
  40. 40.
    zur Hausen H: Intracellular surveillance of persisting viral infections, Human genital cancer results from deficient cellular control of papillomavirus gene expression.Lancet 2, 489 (1986).PubMedCrossRefGoogle Scholar
  41. 41.
    Schneider-Gaedicke A, Schwarz E: Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 genes.EMBO J 5, 2285 (1986).Google Scholar
  42. 42.
    Stanbridge E J, Der C J, Doersen C-J, Nishimi R Y, Peehl D M, Weissman B E, Wilkinson J E: Human cell hybrids: analysis of transformation and tumorigenicity.Science 215, 252 (1982).PubMedCrossRefGoogle Scholar
  43. 43.
    zur Hausen H: The role of viruses in human tumors, in Klein G, Weinhouse S (eds):Advances in Cancer Research, Vol. 33, pp. 77–107 (1980).Google Scholar

Copyright information

© Pergamon Press Ltd. 1987

Authors and Affiliations

  • Harald Zur Hausen
    • 1
  1. 1.Deutsches KrebsforschungszetnrumHeidelberg 1F.R.G.

Personalised recommendations