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Medical Oncology and Tumor Pharmacotherapy

, Volume 4, Issue 3–4, pp 125–132 | Cite as

Quantifying risk and accuracy in cancer risk assessment: The process and its role in risk management problem-solving

  • Angelo Turturro
  • Ronald W. Hart
Editorial
  • 14 Downloads

Abstract

A better understanding of chemical-induced cancer has led to appreciation of similarities to problems addressed by risk management of radiation-induced toxicity. Techniques developed for cancer risk assessment of toxic substances can be generalized to toxic agents. A recent problem-solving approach for risk management of toxic substances developed for the U.S. Department of Health and Human Services, and the role of risk assessment and how uncertainty should be treated within the context of this approach, is discussed. Finally, two different methods, research into the assumptions underlying risk assessment and the modification of risk assessment/risk management documents, are used to illustrate how the technique can be applied.

Key words

Risk assessment Risk management Problem solving Zero risk Assumptions 

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References

  1. 1.
    Interagency Staff Group: Chemical carcinogens: a review of the science and its associated principles.Environ Health Perspect 67, 201 (1986).CrossRefGoogle Scholar
  2. 2.
    Executive Committee DHHS CCERP: Risk assessment and risk management of toxic substances. A report to the Secretary of DHHS (April 1985).Google Scholar
  3. 3.
    Hart R W, Freni S C, Gaylor D W, Gillette J R, Lowry L K, Ward J M, Weisburger E K, Lepore P, Turturro A: Final report of the color additive scientific review panel.Risk Analysis 6, 117 (1986).PubMedCrossRefGoogle Scholar

Copyright information

© Pergamon Press Ltd. 1987

Authors and Affiliations

  • Angelo Turturro
    • 1
  • Ronald W. Hart
    • 1
  1. 1.National Center for Toxicological Research/Food and Drug AdministrationJeffersonU.S.A.

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