Abstract
A pedigree of familial ulcerative colitis with their HLA haplotypes is reported. The mother and two children, the eldest and second of three sons were affected. The mother developed proctitis at age 35, and the lesion extended to the entire colon at the time of a relapse. The two sons developed ulcerative colitis in a similar fashion; total colitis, of moderate severity, developing at age 16 in both. The analysis of HLA haplotypes of all five family members suggested that the HLA responsible for ulcerative colitis in this family was not HLA B, C, or DR, but Aw24 and DQw1. The third son had the same HLA haplotype as the second son, and it was presumed that he would develop ulcerative colitis in the future. These cases, together with other cases of familial ulcerative colitis indicate that Aw24 and DQw1 are critical phenotypes for ulcerative colitis in Japan.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Utsunomiya T, Katsumata T, Nakayama T, et al. Genetic analysis in familial occurrence of patients with ulcerative colitis. Annual Report of the Research Committee of Inflammatory Bowel Disease, The Ministry of Health and Welfare of Japan. 1994; 206–209.
Almy TP, Sherlock P. Genetic aspects of ulcerative colitis and regional enteritis. Gastroenterology 1966;51:757–763.
Delpre G, Kadish U, Gazit E, et al. HLA antigens in ulcerative colitis and Crohn's disease in Israel. Gastroenterology 1980;78:1452–1457.
Pena AS Immunogenetic aspects of inflammatory bowel disease. In: Rotter JI, Samloff IM, Rimoin DL (eds) The genetics and heterogeneity of common gastrointestinal disorders. New York: Academic, 1980;281–289.
Morita N, Shiwake Y, Inoue M. HLA-antigens in patients with ulcerative colitis in Japan. In: Shiratori T, Nakano H (eds) Japan Medical Research Foundation Publication No. 22. Inflammatory bowel disease. Tokyo: University of Tokyo Press, 1984;83–89.
Yagita A, Matsubara Y, Orima I, et al. Evaluation of ulcerative colitis and HLA, particularly class II antigen. A study of 170 patients with ulcerative colitis and two family lines showing familial incidence (in Japanese with English abstract). Nihon Rinsho Geka Gakkai Zasshi (J Jpn Soc Clin Surg) 1987;48:595–601.
Futami S, Aoyama N, Honsako Y, et al. HLA-DRB1*1502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression. Dig Dis Sci 1995;40:814–818.
Goh K, Fukushima T, Yamazaki Y, et al. Familial occurrence of ulcerative colitis (in Japanese with English abstract). Nihon Daicho Komonbyo Gakkai Zasshi (J Jpn Soc Coloproctol) 1990;43:44–49.
Kane T, Bamba T, Chikamochi N, et al. A familial case of ulcerative colitis developed in male identical twins and a female sibling (in Japanese with English abstract). Nihon Shokakinaishikyo Gakkai Zasshi (Gastroenterol Endosc) 1992;34:879–887.
Amano K, Seko A, Sugiyama H, et al. Ulcerative colitis in female siblings with an identical human leukocyte antigen haplotype (A24, Bw52, DR52 and DQw1). Internal Med 1993;32:298–301.
Akagi M, Tanaka S, Yoshihara M, et al. Cases of ulcerative colitis in father and his son—association of HLA antigens with ulcerative colitis in Japan (in Japanese with English abstract). Nihon Daicho Komonbyo Gakkai Zasshi (J Jpn Soc Coloproctol) 1993; 46:787–792.
Satoh K, Nomura M, Ayabe T, et al. Familial occurrence of ulcerative colitis (in Japanese with English abstract). Nihon Daicho Komonbyo Gakkai Zasshi (J Jpn Soc Coloproctol) 1995;48:597–605.
Stern LJ, Brown JH, Jardetzky TS, et al. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994;368:215–221.
Sugimura K, Asakura H, Mizuki N, et al. Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis. Hum Immunol 1993;36:112–118.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kamata, A., Chiba, M., Ishii, N. et al. Three cases of familial ulcerative colitis—in a mother and two of her sons. J Gastroenterol 32, 401–404 (1997). https://doi.org/10.1007/BF02934500
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02934500