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Gastric cancer associated with overexpression of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor in relation to tumor progression

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Abstract

Parathyroid hormone-related peptide (PTHrP) is involved in cell proliferation in both neoplastic and non-neoplastic tissues. We describe an autopsy case of gastric cancer in a patient who showed serum hypercalcemia and overexpression of PTHrP and PTH/PTHrP receptor in the metastatic tumor cells. The primary gastric tumor was poorly differentiated adenocarcinoma, and multiple metastases were present in the bone, multiple visceral organs, peritoneum, and lymph nodes. PTHrP and its mRNA were detected only in the metastatic tumor cells, but not in primary gastric tumor. PTH/PTHrP receptor was also demonstrated immunohistologically in metastatic tumor cells. This case suggests that the expression of PTHrP is related to tumor progression and the poor prognosis in tumors associated with humoral hypercalcemia.

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Authors and Affiliations

  1. Department of Pathology, Department of Cell Physiology, Atomic Disease Institute, Nagasaki University School of Medicine, 1-12-4 Sakamoto, 852, Nagasaki, Japan

    Masahiro Ito, Masahiro Nakashima, Gabit K. Alipov, Sumihiro Matsuzaki, Akira Ohtsuru, Hiroyuki Yano, Shunichi Yamashita & Ichiro Sekine

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  1. Masahiro Ito
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  2. Masahiro Nakashima
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  3. Gabit K. Alipov
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  4. Sumihiro Matsuzaki
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  5. Akira Ohtsuru
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  6. Hiroyuki Yano
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  7. Shunichi Yamashita
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  8. Ichiro Sekine
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Ito, M., Nakashima, M., Alipov, G.K. et al. Gastric cancer associated with overexpression of parathyroid hormone-related peptide (PTHrP) and PTH/PTHrP receptor in relation to tumor progression. J Gastroenterol 32, 396–400 (1997). https://doi.org/10.1007/BF02934499

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  • DOI: https://doi.org/10.1007/BF02934499

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