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Estimation of serum β-2-microglobulin in children with malabsorption disorders syndrome

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Abstract

The aim of this study was to examine serum levels of β-2-microglobulin (b-2-m) in 132 children at various stages for the evaluation of celiac disease (CD). Serum b-2-m was analyzed by a radio immunossay (RIA) method, using a β-2-micro RIA kit (Pharmacia, Uppsala, Sweden). The mean concentration of b-2-m in children with an established diagnosis of CD was 4.38±1.86 mg/l. In children receiving a gluten-free diet, the mean b-2-m concentration was 1.95±1.09mg/l, and in children who received a gluten-containing diet, the concentration was 3.19±0.71mg/l. In children with CD who were on a gluten-free diet and who presented no antibodies against EmA in class IgA serum, b-2-m concentration was within the normal range (1.86±0.55mg/l). The concentration of b-2-m in children with secondary malabsorption syndrome was within the physiological range (1.77±0.64mg/l). In children with IgA-EmA antibodies present in serum, the b-2-m concentration was significantly higher (3.5±1.23mg/l;P<0.001) than that in children with IgA-EmA in serum. We showed a linear dependence between the degree of villous atrophy in CD and concentrations of b-2-m in serum (r 2=0.94). Determination of b-2-m concentration in sera of children with CD may be used to monitor treatment with a gluten-free diet and to differentiate secondary malabsorption syndrome from CD.

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References

  1. Bailey DS, Freedman AR, Price SC, et al. Early biochemical responses of the small intestine of coeliac patients to wheat gluten. Gut 1989;30:78–82.

    Article  PubMed  CAS  Google Scholar 

  2. Kagnoff MF. Celiac disease: A model of immunologically mediated intestinal disease. Immunol Aller Clin North Am 1988;8:505–512.

    Google Scholar 

  3. Kagnoff MF. Immunopathogenesis of celiac disease. Immunol Invest 1989;18:499–505.

    Article  PubMed  CAS  Google Scholar 

  4. Niven MJ, Caffrey C, Sachs JA, et al. Susceptibility to coeliac disease involves genes in HLA-DP region. Lancet 1987;1087:805–812.

    Article  Google Scholar 

  5. Chorzelski TP, Beutner EH, Sulej J, et al. IgA-anti-endomysium antibody. A new immunological marker of dermatitis herpetiformis and coeliac disease. Br J Dermatol 1984;111:395–399.

    Article  PubMed  CAS  Google Scholar 

  6. Zalewski T, Chorzelski TP, Kapuścińska A, et al. Significance of IgA class endomysial antibodies in the diagnosis of celiac disease. In: Chorzelski TP, Beutner EH, Kumar V, Zalewski T (eds) Serological diagnosis of celiac disease. Boca Raton: CRC, 1990;3:87–104.

    Google Scholar 

  7. McNeish AS, Harms HK, Rey J, et al. The diagnosis of coeliac disease: A commentary on the current practices of members of the European Society for Paediatric Gastroenterology and Nutrition (ESPGAN). Arch Dis Child 1979;54:783–788.

    Article  PubMed  CAS  Google Scholar 

  8. Miyakawa Y, Tanigaki N, Kreiter VP, et al. Characterization of soluble substances in the plasma cartying HLA alloantigenic activity and HLA common antigenic activity. Transplantation 1973;15:312–319.

    Article  PubMed  CAS  Google Scholar 

  9. Björkman PJ, Saper MA, Samraoni B, et al. Structure of the human class I histocompatibility antigen HLA-A2. Nature 1987;329:506–512.

    Article  PubMed  Google Scholar 

  10. Michalski JP, Daniels TE, Talal N, et al. Beta-2-microglobulin and lymphocytic infiltration in Sjörgren's syndrome. New Engl J Med 1975;293:1228–1231.

    PubMed  CAS  Google Scholar 

  11. Evrin PE, Strom T. β2-m and its binding activity in serum from patients with SLE. Ann Rheum Dis 1984;43:267–273.

    Article  PubMed  CAS  Google Scholar 

  12. Brousse A, P le Goff, Morin PP. Notre experience du dosage de la beta-2-microglobulin serique en rhumatologie. Rev Rhum 1984;51:25–27.

    PubMed  CAS  Google Scholar 

  13. Zolla-Pazner S, William D, El-Sadr W, et al. Quantitation of beta-2-microglobulin and other immune characteristics in a prospective study of men at risk for acquired immune deficiency syndrome. JAMA 1984;251:2951–2955.

    Article  PubMed  CAS  Google Scholar 

  14. Kochańska-Dziurowicz A, Starzewski JJ, Dunal W. Estimation of the value of serum β2-microglobulin concentration in the diagnosis of Hashimoto's disease. Clin Chim Acta 1995;223:101–104.

    Article  Google Scholar 

  15. Levrang HH, Moller-Peterson J, Ditzel J. Serum beta-2-microglobulin levels in thyroid disease. J Intern Med 1989; 226:261–264.

    Google Scholar 

  16. Kochańska-Dziurowicz AA. Concentration of beta-2-microglobulin in serum with immunological disease of thyroid gland (PhD thesis, in Polish). Ann Med Acad 1994:1–95.

  17. Walker-Smith JA, Guandalini S, Schmitz J. Revised criteria for diagnosis of celiac disease. Report of Working Group of European Society of Paediatric Gastroenterology and Nutrition (ESPGAN). Arch Dis Child 1990;8:909–911.

    Google Scholar 

  18. Kraińska T, Sulej J, Kowalewski C, et al. Detection of specific marker for gluten-dependent enteropathy by immunoperoxidase and immunofluorescent methods (in Polish). Derm Rev 1988; 75:123–128.

    Google Scholar 

  19. Blanco A, Alonso M, Cillerulo ML, et al. Increased serum beta-2-microglobulin levels in active celiac disease. J Pediatr Gastroenterol Nutr 1985;4:388–392.

    PubMed  CAS  Google Scholar 

  20. Bonamico M, Culassa F, Pitzalis G, et al. Beta-2-microglobulin levels in celiac disease. J Pediatr Gastroenterol Nutr 1990;11:330–336.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Nuclear Medicine, Institute of Occupational Medicine and Environmental Health, Kościelna 13, 41-200, Sosnowiec, Poland

    Aleksandra Kochańska-Dziurowicz

  2. Third Department of Pediatric Clinical, Silesian Medical Academy, Batorego 15, Bytom, Poland

    Celina Bukowska

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  1. Aleksandra Kochańska-Dziurowicz
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  2. Celina Bukowska
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Kochańska-Dziurowicz, A., Bukowska, C. Estimation of serum β-2-microglobulin in children with malabsorption disorders syndrome. J Gastroenterol 32, 312–317 (1997). https://doi.org/10.1007/BF02934486

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  • DOI: https://doi.org/10.1007/BF02934486

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