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Analysis of bile acids in colon residual liquid or fecal material in patients with colorectal neoplasia and control subjects

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Abstract

Bile acids are believed to play a role in the etiology of colorectal cancer. To examine the relationship between bile acids and colorectal neoplasia, bile acids in colon residual liquid or fecal material were analyzed in 18 patients with colorectal adenoma, 12 patients with colorectal cancer, and 18 healthy control subjects. High-performance liquid chromatography combined with immobilized 3α-hydroxysteroid dehydrogenase in column form showed a significant evevation in the proportion of deoxycholic acid (P<0.05), lithocholic acid (P<0.05), secondary bile acids (deoxycholic acid plus lithocholic acid) (P<0.02), and the chenodeoxycholic acid-lithocholic acid family (chenodeoxycholic acid plus lithocholic acid) (P<0.05) in the colon residual liquid or fecal material of the patients with colorectal adenoma compared with proportions in the control subjects. A similar trend was noted in the patients with colorectal cancer compared to the control subjects. These findings suggested that an increase in the proportion of secondary bile acids, in particular, of lithocholic acid, was closely related to the pathogenesis of colorectal neoplasia.

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Authors and Affiliations

  1. Third Department of Internal Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113, Tokyo, Japan

    Teruyuki Kishida, Fumihiko Taguchi, Li Feng, Atsushi Tatsuguchi, Jun Sato, Shunji Fujimori, Hironori Tachikawa, Yasuhito Tamagawa, Yutaka Yoshida & Masafumi Kobayashi

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  1. Teruyuki Kishida
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  2. Fumihiko Taguchi
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  3. Li Feng
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  4. Atsushi Tatsuguchi
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  5. Jun Sato
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  6. Shunji Fujimori
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  7. Hironori Tachikawa
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  8. Yasuhito Tamagawa
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  9. Yutaka Yoshida
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  10. Masafumi Kobayashi
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Kishida, T., Taguchi, F., Feng, L. et al. Analysis of bile acids in colon residual liquid or fecal material in patients with colorectal neoplasia and control subjects. J Gastroenterol 32, 306–311 (1997). https://doi.org/10.1007/BF02934485

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  • DOI: https://doi.org/10.1007/BF02934485

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