Clinical and experimental study of shuangcao tuihuang Granule- 1 in treating severe jaundice of acute icterohepatitis

Abstract

Objective

To observe the effect of Shuangcao Tuihuang Granule-1 (SCTH-1) in treating severe jaundice of acute icterohepatitis and to study its mechanism.

Methods

Thirty-four patients with severe jaundice of acute icterohepatitis were treated with conventional western medicine and SCTH-1, the therapeutic effects were analyzed and compared with that in the control group (treated with western medicine alone). In the animal experimental studies, the influences of SCTH-1 on acute liver injury, liver superoxide dismutase (SOD) and serum ALT and AST in mice were monitored.

Results

The markedly effective rate in the treated group and the control group was 73. 5% and 59.1% respectively, and the effective rate was 23.5% and 40. 9% respectively. The markedly effective rate in the treated group was obviously higher than that in the control group (P <0.05). Experimental study showed that SCTH-1 could reduce the level of serum transaminase and liver tissue damage in mice with acute liver damage. In addition, SCTH-1 could raise the activity of liver SOD (p<0. 05).

Conclusion

SCTH-1 could accelerate the jaundice subsidence, improve the liver function and ameliorate the liver injury, its mechanism was possibly correlated with raising SOD activity and scavenging oxygen free radicals.