Effects of Qiwei Baizhu San in inhibiting replication of human rotavirus in vitro) in inhibiting replication of human rotavirus in vitro

Abstract

Qiwei Baizhu San was found to have an inhibitory effect on human rotavirus at monolayers of MA₁₀₄ cells. A 50% reduction in plaque number, a 10^1.86 TCID₅₀ decrease in viral replication index and an around 60% inhibition in viral RNA synthesis were observed at concentration of 100 mg/ml. Furthermore, the cytotoxicity of the decoction was low, while its promoting effect on growth and proliferation of the culture cells was observed at the concentrations of 12.5~50 mg/ml. The decoction was also found to have effects in prolonging the survival time of infected cells with rotavirus and promoting the regeneration of the infected cells.