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Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3

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Abstract

Here was investigated the effect of Radix Astragalus Membranaceus (AM) on Ca2+ influx across the myocardial plasma membrane and coxsackie virus B3(CVB3)-RNA replication in cultured neonatal rat heart cells infected with CVB3. It was found that the Ca2+ influx could be inhibited significantly by AM both in heart cells infected with CVB3 for 48 hours and in normal control heart cells. In addition, the Ca2+ influx and the amounts of CVB3-RNA in myocytes simultaneously infected with CVB3 and treated with AM for 48 hours were statistically decreased compared with that in CVB3-infected control cells. These phenomena suggested that AM could exert the effects of decreasing the secondary Ca2+ damages, improving the abnormal myocardial electric activity and inhibiting replication of CVB3-RNA in myocardium. Thus, it is a rational choice to treat patients with AM in viral myocarditis.

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Authors and Affiliations

  1. Shanghai Institute of Cardiovascular Diseases, Zhong Shan Hospital of Shanghai Medical University, 200032, Shanghai

    Qi Guo, Tian-Qing Peng & Ying-Zhen Yang

  2. Shanghai Institute of Cell Biology, Academia Sinica, 200031, Shanghai

    Quan-Bao Gu & Jian-Xing Zhao

Authors
  1. Qi Guo
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  2. Tian-Qing Peng
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  3. Ying-Zhen Yang
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  4. Quan-Bao Gu
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  5. Jian-Xing Zhao
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Guo, Q., Peng, TQ., Yang, YZ. et al. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3. CJIM 2, 64–67 (1996). https://doi.org/10.1007/BF02934230

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  • DOI: https://doi.org/10.1007/BF02934230

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