Skip to main content
SpringerLink
Log in

Effect of total saponins of Ginseng leaves on immunity in aged rats

  • Experimental Work and Research
  • Published:
Chinese Journal of Integrated Traditional and Western Medicine Aims and scope Submit manuscript

Abstract

Objective: To explore the effect of total saponins of Ginseng leaves(GS) on the functions of neutrophil and lymphocyte in the aged rats of 20 months.Methods: Three groups of aged rats were injected intraperiton-eally with doses of 12.5 mg/kg, 25 kg/mg and 50 mg/kg of GS once daily for 3 days, the declined immunity of spleen lymphocytes (proliferation of spleen lymphocyte, phagocytosis), superoxide anion and nitric oxide formation were studied and were compared with those of young rats (2 months).Results: The declined immunity of spleen lymphocytes were improved dose-dependently after GS injected.Conclusion: The results indicate that GS may enhance neutrophil and lymphocyte mediated non-specific and specific defense function in aged rats.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Makinodan T, Kay MB. Age influences on the immune system. In Kungel HG and Dixon FJ Eds. Advances of Immunology. New York: Academic Press, 1980: 287–330.

    Google Scholar 

  2. Antonaci S. Non-specific immnunity in aging: deficiency in monocyte and polymorphonuclear cell-mediated functions. Mech Age Dev 1980; 24: 367–375.

    Article  Google Scholar 

  3. 2 1991: 1218–1233.

  4. Stossel TP. Evaluation of opsonic and leukocyte function and with phagocytic disorders. Blood 1973; 42: 121–130.

    PubMed  CAS  Google Scholar 

  5. Segal AW, Coade SB. Kinetic of oxygen consumption by phagocytosing human neutrophils. Biochem Biophys Res Commun 1978; 84: 611–617.

    Article  PubMed  CAS  Google Scholar 

  6. Grisham MB, Ware K, GillelandHE Jr, et al. Neutrophilmediated nitrosamine formation: role of nitric oxide in rats. Gastroenterology 1992; 103: 1260.

    PubMed  CAS  Google Scholar 

  7. Nordin AA and Makinodan T. Humoral immunity in aging. Fedr Proc 1974; 33: 2033.

    CAS  Google Scholar 

  8. Hori Y, Perkins EH and Halsall MK. Decline in phyto hemagglutinin responsiveness of spleen cells from aging mice. Proc Soc Exp Biol Med 1973; 144: 48.

    PubMed  CAS  Google Scholar 

  9. Niwa Y, Kasama T, Miyachi Y, et al. Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: cross-sectional and logitudinal studies. Life Sci 1989; 44: 1655.

    Article  PubMed  CAS  Google Scholar 

  10. Moncada S and Higgs EA. Endogenous nitric oxide: physiology, pathology and clinical relevance. Eur J Clin Invest 1991c; 21: 361.

    Article  PubMed  CAS  Google Scholar 

  11. 1985: 223.

Download references

Author information

Authors and Affiliations

  1. Beijing Hospital, National Center for Clinical Laboratories, 100730, Beijing

    Zhang Kejian

  2. Institute of Materia Medica, Chinese Academy of Medical Sciences, 100730, Beijing

    Liu Gengtao

Authors
  1. Zhang Kejian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Liu Gengtao
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kejian, Z., Gengtao, L. Effect of total saponins of Ginseng leaves on immunity in aged rats. CJIM 5, 50–53 (1999). https://doi.org/10.1007/BF02934191

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02934191

Key Words

Search

Navigation