Effect of Yunqi decoction on esophageal mucosal morphology and esophageal motility in reflux esophagitis patients) on esophageal mucosal morphology and esophageal motility in reflux esophagitis patients

Abstract

Objective: To observe the effects of Yunqi decoction (

, YQD) on both esophageal mucosal morphology and esophageal motility in patients with reflux esophagitis (RE).Methods: According to syndrome differentiation of traditional Chinese medicine (TCM), 42 RE patients were divided into three groups: disharmony of Liver and Stomach (group D), Deficiency-Cold of Spleen and Stomach (Group DC), Heat Syndrome caused by stagnation of Liver Qi (Group H). No. I, II, III of YQD were taken respectively for 4 weeks. Before and after treatment scores of typical symptoms were collected, gastroscopy was performed and esophageal motility were measured.Results: (1) The symptom remission rate was 81.1%, there were significant differences between the group DC with group D and group H(P < 0.01). (2) The esophageal mucosal healing rate was 61.9%, the effective rate was 90.5%, and the ineffective rate was 9.5%. There were not significant differences of effective rate among the three groups (P>0.05). (3) The changes of esophageal motility: Lower esophageal sphincter pressure (LESP) and average peristaltic pressure (APP) of group D were obviously higher than before treatment (P < 0.05), LESP, gastro-esophageal barrier pressure (GEBP) and peristaltic conduct speed (PCS) of group DC were remarkably higher (P < 0.05). GEBP of group H was improved (P < 0.05). Conclusions: YQD has a good therapeutic effect. It’s not only resolving reflux esophageal symptoms, healing esophageal mucosa, but also improving esophageal motile function.