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Treatment of Liver fibrosis of hepatitis B by interferon-α1 and traditional medicine preparationΔ

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Abstract

Objective: To find the effective method of curing liver fibrosis of hepatitis B.Methods: Using interferon-α1 (IFN-α1) and traditional Chinese medicine (TCM) preparation to treat the patients with liver fibrosis of hepatitis B and observe the changes of indexes including levels of laminin, precollagen type III, hyaluronic acid, liver puncture, ultrasonography and fibergastroscopy before and after treatment.Results: After 3 months treatment, the indexes were lower than those before treatment. There was a significant difference (P < 0.01). Liver biopsy, ultrasonography and fiber-gastroscopy proved that the liver fibrosis was improved. After 6 months the indexes of the hepatofibrosis, blood albumin and globulin levels showed that the differences between the IFN-effective group and the IFN-ineffective group was significant (P < 0.001).Conclusion: Beneficial effect might be obtained by using IFN-cq to suppress the replication of hepatitis B virus and TCM preparation to treat liver fibrosis.

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Authors and Affiliations

  1. Department of Infectious Disease, Affiliated Hospital of Guiyang Medical College, 550004, Guiyang

    Cheng Mingliang, Wu Yayun, Huang Kefu, Luo Tianyong, Ding Yisheng, Lu Yinying, Liu Rencai & Wu Jun

Authors
  1. Cheng Mingliang
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  2. Wu Yayun
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  3. Huang Kefu
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  4. Luo Tianyong
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  5. Ding Yisheng
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  6. Lu Yinying
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  7. Liu Rencai
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  8. Wu Jun
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Additional information

Δ Supported by the ”8.5” key project of scientific commission of Guizhou province (1993 No. 2037) and the ”9. 5” brainstormed project of scientific commission of Guizhou province. (1996 No. 1028)

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Mingliang, C., Yayun, W., Kefu, H. et al. Treatment of Liver fibrosis of hepatitis B by interferon-α1 and traditional medicine preparationΔ . CJIM 5, 16–19 (1999). https://doi.org/10.1007/BF02934181

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  • DOI: https://doi.org/10.1007/BF02934181

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