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Rosin microparticles as drug carriers: Influence of various solvents on the formation of particles and sustained-release of indomethacin

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Abstract

The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a dispersion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the formation of colloidal microparitcles, various solvents like ethanol, DMF, DMAc, and acetone were used. The rosin microparticles containing IND were characterized by X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). The morphologies of rosin microparticles observed by scanning electron microscopy (SEM) were spherical. The solvents used to dissolve rosin significantly affected the drug content and drug release rate of IND. The release behaviors of IND from the rosin microparticles were dependent on the drug content and size of the particles. Rosin microparticles with a higher drug content and of a larger particle size had a slower drug release rate. Also, the IND release rate from the rosin microparticles could be regulated by the rosin content in the microparticles. From these results, rosin microparticles have the potential of being used as a sustained release system of IND.

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Authors and Affiliations

  1. Interdisciplinary Program of Biomedical Engineering, Chonnam National University, 500-757, Gwangju, Korea

    Chang-Moon Lee

  2. Ecobio Inc., Business Incubation Center, Chonnam National University, 500-757, Gwangju, Korea

    Seung Lim & Gwang-Yun Kim

  3. School of biological Sciences and Technology and Research Institute for Catalysis, Chonnam National University, 500-757, Gwangju, Korea

    Doman Kim

  4. Department of Health and Hygiene, Gwang-Yang Health College, 545-703, Jeonnam, Korea

    Dong-Woon Kim

  5. Department of Microbiology, Chonnam National University Medical School, 501-190, Gwangju, Korea

    Hyun-Chul Lee

  6. Department of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University, 500-757, Gwangju, Korea

    Ki-Young Lee

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  1. Chang-Moon Lee
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  2. Seung Lim
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  3. Gwang-Yun Kim
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Correspondence to Ki-Young Lee.

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Lee, CM., Lim, S., Kim, GY. et al. Rosin microparticles as drug carriers: Influence of various solvents on the formation of particles and sustained-release of indomethacin. Biotechnol. Bioprocess Eng. 9, 476–481 (2004). https://doi.org/10.1007/BF02933489

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  • DOI: https://doi.org/10.1007/BF02933489

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