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Activation of human B lymphocytes

Thein vitro polyclonal B cell activator-induced plaque-forming cell system

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Ricerca in clinica e in laboratorio

Summary

The characteristics of human B lymphocyte triggering, differentiation, and regulation are described using the polyclonally induced anti-sheep red blood cell hemolytic plaque-forming cell assay system. Technical and methodologic considerations, cellular requirements and mechanisms of regulation including suppressor and helper influences are discussed. Also considered are theoretical concepts regarding normal immune response versus pathologic immune states and the potential biologic role of polyclonal activation in these human immune mechanisms.

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  1. Clinical Physiology Section, Laboratory of Clinical Investigation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11B13, 20205, Bethesda, Md, USA

    Karen R. Kingry & Anthony S. Fauci

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  1. Karen R. Kingry
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  2. Anthony S. Fauci
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Kingry, K.R., Fauci, A.S. Activation of human B lymphocytes. La Ricerca Clin. Lab. 9, 207–221 (1979). https://doi.org/10.1007/BF02932173

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