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Effect of oral application of a probioticE. coli strain on the intestinal microflora of children of allergic mothers during the first year of life

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Abstract

Influence of intestinal colonization by a probioticE. coli strain on the incidence of bacterial pathogens in stool and allergic symptoms during the 1st year of life was monitored in 3 groups: colonized children of allergic mothers (AC;n=52), noncolonized children of allergic mothers (AN;n=50), children of nonallergic mothers (NC;n=42). Colinfant vaccine was administered within 2 d after birth, 3× a week over a period of 4 weeks. Stool samples were examined after 2 d and at the age of 3, 6 and 12 months. At 3 monthsE. coli was present in 90 %, at 12 months in 73 % of AC. Pathogens were significantly less frequent on day 3 and at 3 months in ACvs. AN (15vs. 61 %,p<0.001; 15vs. 38 %,p<0.01) andvs. NC (15vs. 63 %,p<0.001; 15vs. 53 %,p<0.001). AC exhibited lower incidence ofStaphylococcus epidermidis than AN on day 3 (6vs. 31 %,p<0.001) and ofKlebsiella strains on day 3 and at 3 months (4vs. 20 %,p<0.05; 5vs. 24 %,p<0.01). AC showed a lower incidence ofPseudomonas aeruginosa than NC on day 3 (6vs. 31 %,p<0.01) andKlebsiella spp. on day 3 and at 3 months (4vs. 22 %,p<0.05; 5vs. 45 %,p<0.001). No significant differences were recorded after 6 and 12 months. The incidence of allergies was 3 % in AC, 26 % in AN (p<0.01), and 10 % in NC.

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Abbreviations

AC:

colonized children of allergic mothers

NC:

children of nonallergic mothers

AN:

noncolonized children of allergic mothers

TGF-β:

transforming growth factor β

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Authors and Affiliations

  1. Institute for Care of Mother and Child, 147 10, Prague, Czechia

    I. Kocourková & R. Žádníková

  2. Institute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University, Prague, Czechia

    J. Žižka

  3. Institute of Clinical Biochemistry and Laboratory Diagnostics, Prague, Czechia

    V. Rosová

Authors
  1. I. Kocourková
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  2. R. Žádníková
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  3. J. Žižka
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  4. V. Rosová
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Corresponding author

Correspondence to I. Kocourková.

Additional information

This work was supported by theMinistry of Public Health of the Czech Republic (Internal Grant Agency project 7525-3).

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Kocourková, I., Žádníková, R., Žižka, J. et al. Effect of oral application of a probioticE. coli strain on the intestinal microflora of children of allergic mothers during the first year of life. Folia Microbiol 52, 189–193 (2007). https://doi.org/10.1007/BF02932158

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  • DOI: https://doi.org/10.1007/BF02932158

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