Effect of root canal sealers on mouse peritoneal macrophage functions
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Three root canal filling materials,viz. calcium hydroxide-based cement (Apexit®, resin-based cement (AH-plus®) and glass-ionomer based material (Ketac Endo®) were tested for their influence on several functions of peritoneal macrophages from Balb/c mice. Macrophage functions were evaluated by the adherence, phagocytic, candidacidal and Nitro blue tetrazolium-dye assays. Ketac-Endo® enhanced all macrophage functions in the first 2 d (p≤0.05), when compared to the positive control, but this effect had changed after 7 and 14 d, causing inhibition of these functions. Other materials suppressed substrate adherence capacity and phagocytosis, while significantly stimulating macrophage microbicidal activity (p≤0.05) in a time-dependent manner.
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